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volume of distribution; pool fraction THE MOST abundant amino acid in human plasma and muscle (1, 24), is the major vehicle for the interorgan transport of nitrogen (12) and carbon (20). Its flux through plasma is therefore likely to change under a variety of conditions (5, 7, 16, 18). To date, plasma flux has been measured only under steady-state conditions (4-7,16-l& 20). Measurement of plasma flux under non-steady-state conditions has not been validated, and little or no information is available concerning the volume of distribution, pool fraction, and appropriate number of compartments to be used in calculations applied to the nonsteady state (6). Most studies of plasma have used nitrogen-labeled tracers (4-7, 16-18). Recently, however, investigators have begun to employ carbonlabeled tracers (11, 26, 27), and one study has used a , 0193-1849/97 $5.00 Copyright o 1997 hydrogen-labeled tracer (11). As has been shown for alanine (31), different tracers can yield different values for rates of plasma , depending on the metabolic fate of the portion of the molecule labeled. In general, rates of plasma in normal postabsorptive human adults measured with the use of a [2-ljN] tracer have been lower than those measured with a carbon-labeled tracer
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Apr 1, 1997
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