Splanchnic vasoconstriction in heat-stressed men: role of renin-angiotensin system

Splanchnic vasoconstriction in heat-stressed men: role of renin-angiotensin system ESCOURROU, P., P. R. FREUND, L. B. ROWELL, D. G. JOHNSON. in heat-stressed men: roZe of system. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 52(6): 1438-1443, 1982.-We conducted a two-part study to determine whether the system contributes to the rise in vascular resistance (SVR) during heat stress (rectal temperature was raised 1 “C). In experiment 1 (control) seven men on a normal salt diet were directly heated (water-perfused suits) for 40-50 min. Arterial pressure (85 Torr) was unchanged; plasma renin activity (PRA) rose from 102 to 239 ng angiotensin I.100 ml-‘. 73% (from 63 to 109 units). Experi3 h-l; SVR increased ment 2 was a repetition of experiment 1 on the same subjects, except that propranolol (10 mg iv) was given at the onset of to block renin release. Propranolol attenuated the rise in heart rate reduced mean arterial pressure from 82 to 72 Torr; it blocked the rise in PRA with in two subjects, reduced it in three, but increased it in two. Although changes in SVR paralleled those in PRA in three subjects, SVR still rose 60% (from 58 to 99 units) after PRA rise was blocked. In both experiments, plasma norepinephrine concentration rose indicating increased http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Splanchnic vasoconstriction in heat-stressed men: role of renin-angiotensin system

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Publisher
The American Physiological Society
Copyright
Copyright © 1982 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
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Abstract

ESCOURROU, P., P. R. FREUND, L. B. ROWELL, D. G. JOHNSON. in heat-stressed men: roZe of system. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 52(6): 1438-1443, 1982.-We conducted a two-part study to determine whether the system contributes to the rise in vascular resistance (SVR) during heat stress (rectal temperature was raised 1 “C). In experiment 1 (control) seven men on a normal salt diet were directly heated (water-perfused suits) for 40-50 min. Arterial pressure (85 Torr) was unchanged; plasma renin activity (PRA) rose from 102 to 239 ng angiotensin I.100 ml-‘. 73% (from 63 to 109 units). Experi3 h-l; SVR increased ment 2 was a repetition of experiment 1 on the same subjects, except that propranolol (10 mg iv) was given at the onset of to block renin release. Propranolol attenuated the rise in heart rate reduced mean arterial pressure from 82 to 72 Torr; it blocked the rise in PRA with in two subjects, reduced it in three, but increased it in two. Although changes in SVR paralleled those in PRA in three subjects, SVR still rose 60% (from 58 to 99 units) after PRA rise was blocked. In both experiments, plasma norepinephrine concentration rose indicating increased

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: Jun 1, 1982

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