Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Matthay (2001)
Severe sepsis--a new treatment with both anticoagulant and antiinflammatory properties.The New England journal of medicine, 344 10
C. Nobes, A. Hall (1995)
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodiaCell, 81
J. Jacobson, S. Dudek, K. Birukov, S. Ye, D. Grigoryev, R. Girgis, Joe Garcia (2004)
Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin.American journal of respiratory cell and molecular biology, 30 5
A. Brazma, P. Hingamp, John Quackenbush, G. Sherlock, P. Spellman, C. Stoeckert, J. Aach, W. Ansorge, C. Ball, H. Causton, T. Gaasterland, Patrick Glenisson, F. Holstege, Irene Kim, V. Markowitz, J. Matese, H. Parkinson, A. Robinson, Ugis Sarkans, S. Schulze-Kremer, Jason Stewart, Ronald Taylor, J. Vilo, M. Vingron (2001)
Minimum information about a microarray experiment (MIAME)—toward standards for microarray dataNature Genetics, 29
K. Fassbender, M. Simons, C. Bergmann, M. Stroick, D. Lütjohann, P. Keller, H. Runz, S. Kühl, T. Bertsch, K. Bergmann, M. Hennerici, K. Beyreuther, T. Hartmann (2001)
Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivoProceedings of the National Academy of Sciences of the United States of America, 98
C. Brun-Buisson, C. Minelli, G. Bertolini, L. Brazzi, J. Pimentel, K. Lewandowski, J. Bion, J. Romand, J. Villar, A. Thorsteinsson, P. Damas, A. Armaganidis, F. Lemaire (2004)
Erratum: Epidemiology and outcome of acute lung injury in European intensive care units: Results from the ALIVE study (Intensive Care Medicine (2003) 30 (51-61)), 30
C. Brun-Buisson, C. Minelli, G. Bertolini, L. Brazzi, J. Pimentel, K. Lewandowski, J. Bion, J. Romand, J. Villar, A. Thorsteinsson, P. Damas, A. Armaganidis, F. Lemaire (2004)
Epidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study.Intensive care medicine, 30 1
F. Curzon, R. Cobb, S. Mikoshiba (1992)
Control of repetitive electrical discharges by means of an external electrodeJournal of Applied Physics, 72
A. Ayala, C. Chung, J. Lomas, G. Song, L. Doughty, S. Gregory, W. Cioffi, B. Leblanc, J. Reichner, H. Simms, P. Grutkoski (2002)
Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency.The American journal of pathology, 161 6
T. Green, Dana Johnson, R. Marchessault, C. Gatto (1988)
Transvascular flux and tissue accrual of Evans blue: effects of endotoxin and histamine.The Journal of laboratory and clinical medicine, 111 2
K. Fassbender, M. Simons, C. Bergmann, M. Stroick, D. Lutjohann, P. Keller, H. Runz, S. Kuhl, T. Bertsch, K. Bergmann, M. Hennerici, K. Beyreuther, T. Hartmann (2001)
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.Proceedings of the National Academy of Sciences of the United States of America, 98 10
Joe Garcia, Feng Liu, A. Verin, A. Birukova, M. Dechert, W. Gerthoffer, James Bamberg, D. English (2001)
Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement.The Journal of clinical investigation, 108 5
Feng Liu, K. Schaphorst, A. Verin, K. Jacobs, A. Birukova, R. Day, N. Bogatcheva, D. Bottaro, Joe Garcia (2002)
Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase‐3βThe FASEB Journal, 16
C. Patterson, R. Rhoades, Joe Garcia (1992)
Evans blue dye as a marker of albumin clearance in cultured endothelial monolayer and isolated lung.Journal of applied physiology, 72 3
M. Jison, P. Munson, J. Barb, A. Suffredini, Shefali Talwar, C. Logun, N. Raghavachari, J. Beigel, J. Shelhamer, R. Danner, M. Gladwin (2004)
Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease.Blood, 104 1
K. Birukov, J. Jacobson, Alejandro Flores, S. Ye, A. Birukova, A. Verin, Joe Garcia (2003)
Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch.American journal of physiology. Lung cellular and molecular physiology, 285 4
C. Heeschen, C. Hamm, U. Laufs, S. Snapinn, M. Böhm, H. White (2002)
Withdrawal of Statins Increases Event Rates in Patients With Acute Coronary SyndromesCirculation: Journal of the American Heart Association, 105
M. Ashburner, C. Ball, J. Blake, D. Botstein, Heather Butler, J. Cherry, A. Davis, K. Dolinski, S. Dwight, J. Eppig, M. Harris, D. Hill, L. Issel-Tarver, A. Kasarskis, S. Lewis, J. Matese, J. Richardson, M. Ringwald, G. Rubin, G. Sherlock (2000)
Gene Ontology: tool for the unification of biologyNature Genetics, 25
K. Barsness, J. Arcaroli, A. Harken, E. Abraham, A. Banerjee, L. Reznikov, R. McIntyre (2004)
Hemorrhage-induced acute lung injury is TLR-4 dependent.American journal of physiology. Regulatory, integrative and comparative physiology, 287 3
Sepideh Amin-Hanjani, N. Stagliano, Masaru Yamada, Paul Huang, James Liao, Michael Moskowitz (2001)
Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice.Stroke, 32 4
M. Olman, K. White, L. Ware, W. Simmons, E. Benveniste, Shan Zhu, J. Pugin, M. Matthay (2004)
Pulmonary Edema Fluid from Patients with Early Lung Injury Stimulates Fibroblast Proliferation through IL-1β-Induced IL-6 Expression 1The Journal of Immunology, 172
R. Godiska, D. Chantry, C. Raport, S. Sozzani, P. Allavena, D. Leviten, A. Mantovani, P. Gray (1997)
Human Macrophage–derived Chemokine (MDC), a Novel Chemoattractant for Monocytes, Monocyte-derived Dendritic Cells, and Natural Killer CellsThe Journal of Experimental Medicine, 185
S. Dudek, Joe Garcia (2001)
Cytoskeletal regulation of pulmonary vascular permeability.Journal of applied physiology, 91 4
S. Dudek, J. Jacobson, E. Chiang, K. Birukov, Peiyi Wang, X. Zhan, Joe Garcia (2004)
Pulmonary Endothelial Cell Barrier Enhancement by Sphingosine 1-PhosphateJournal of Biological Chemistry, 279
M. Whalin, W. Taylor (2004)
Rounding up the usual suspects in atherosclerosis. Focus on "Growth factors induce monocyte binding to vascular smooth muscle".American journal of physiology. Cell physiology, 287 3
Scott Doniger, N. Salomonis, K. Dahlquist, K. Vranizan, Steven Lawlor, B. Conklin (2003)
MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray dataGenome Biology, 4
B. Wojciak-Stothard, S. Potempa, T. Eichholtz, A. Ridley (2001)
Rho and Rac but not Cdc42 regulate endothelial cell permeability.Journal of cell science, 114 Pt 7
T. Kusama, M. Mukai, T. Iwasaki, M. Tatsuta, Y. Matsumoto, H. Akedo, M. Inoue, Hiroyuki Nakamura (2002)
3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis.Gastroenterology, 122 2
Xinqi Peng, P. Hassoun, S. Sammani, B. McVerry, M. Burne, H. Rabb, D. Pearse, R. Tuder, Joe Garcia (2004)
Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury.American journal of respiratory and critical care medicine, 169 11
D. Grigoryev, Shwu-Fan Ma, R. Irizarry, S. Ye, John Quackenbush, Joe Garcia (2004)
Orthologous gene-expression profiling in multi-species models: search for candidate genesGenome Biology, 5
G. O'Driscoll, D. Green, R. Taylor (1997)
Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month.Circulation, 95 5
A. Ridley, H. Paterson, C. Johnston, D. Diekmann, A. Hall (1992)
The small GTP-binding protein rac regulates growth factor-induced membrane rufflingCell, 70
Z. Xing, J. Gauldie, G. Cox, H. Baumann, M. Jordana, Xue-feng Lei, Michelle Achong (1998)
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.The Journal of clinical investigation, 101 2
T. Kita, M. Brown, J. Goldstein (1980)
Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase.The Journal of clinical investigation, 66 5
N. MacCallum, T. Evans (2005)
Epidemiology of acute lung injuryCurrent Opinion in Critical Care, 11
B. Leung, N. Sattar, A. Crilly, M. Prach, D. Mccarey, H. Payne, R. Madhok, C. Campbell, J. Gracie, F. Liew, I. McInnes (2003)
A Novel Anti-Inflammatory Role for Simvastatin in Inflammatory Arthritis
(2005)
SIMVASTATIN REDUCES MURINE ALI AJP-Lung Cell Mol Physiol
C. Brun-Buisson, C. Minelli, G. Bertolini, L. Brazzi, J. Pimentel, K. Lewandowski, J. Bion, J. Romand, J. Villar, A. Thorsteinsson, P. Damas, A. Armaganidis, F. Lemaire, F. Group (2004)
Epidemiology and outcome of acute lung injury in European intensive care unitsIntensive Care Medicine, 30
Jeffrey Wright, J. Christman (2003)
The Role of Nuclear Factor Kappa B in the Pathogenesis of Pulmonary Diseases: Implications for TherapyAmerican Journal of Respiratory Medicine, 2
R. Irizarry, B. Bolstad, F. Collin, L. Cope, Bridget Hobbs, T. Speed (2003)
Summaries of Affymetrix GeneChip probe level data.Nucleic acids research, 31 4
T. Cappola, L. Cope, Amy Cernetich, L. Barouch, Khalid Minhas, R. Irizarry, G. Parmigiani, Sarfraz Durrani, T. Lavoie, E. Hoffman, S. Ye, Joe Garcia, J. Hare (2003)
Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy.Physiological genomics, 14 1
G. Amerongen, M. Vermeer, P. Nègre‐Aminou, J. Lankelma, J. Emeis, V. Hinsbergh (2000)
Simvastatin Improves Disturbed Endothelial Barrier FunctionCirculation: Journal of the American Heart Association, 102
M. Mahadevappa, J. Warrington (1999)
A high-density probe array sample preparation method using 10- to 100-fold fewer cellsNature Biotechnology, 17
Therapies to limit the life-threatening vascular leak observed in patients with acute lung injury (ALI) are currently lacking. We explored the effect of simvastatin, a 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitor that mediates endothelial cell barrier protection in vitro, in a murine inflammatory model of ALI. C57BL/6J mice were treated with simvastatin (5 or 20 mg/kg body wt via intraperitoneal injection) 24 h before and again concomitantly with intratracheally administered LPS (2 µg/g body wt). Inflammatory indexes bronchoalveolar lavage (BAL) myeloperoxidase activity and total neutrophil counts assessed at 24 h with histological confirmation were markedly increased after LPS alone but significantly reduced in mice that also received simvastatin (20 mg/kg; ∼35–60% reduction). Simvastatin also decreased BAL albumin (∼50% reduction) and Evans blue albumin dye extravasation into lung tissue (100%) consistent with barrier protection. Finally, the sustained nature of simvastatin-mediated lung protection was assessed by analysis of simvastatin-induced gene expression (Affymetrix platform). LPS-mediated lung gene expression was significantly modulated by simvastatin within a number of gene ontologies (e.g., inflammation and immune response, NF-κB regulation) and with respect to individual genes implicated in the development or severity of ALI (e.g., IL-6, Toll-like receptor 4). Together, these findings confirm significant protection by simvastatin on LPS-induced lung vascular leak and inflammation and implicate a potential role for statins in the management of ALI. acute lung injury; endothelial; microarrays Address for reprint requests and other correspondence: Joe G. N. Garcia, Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 (E-mail: drgarcia@jhmi.edu )
AJP - Lung Cellular and Molecular Physiology – The American Physiological Society
Published: Jun 1, 2005
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.