Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Abstract One of the theories proposed to explain the action of mineralocorticoids on target tissues attributes their effect on cation transport to stimulation of the “sodium pump.” To test this hypothesis we evaluated the short-term effect of aldosterone on Na-K-ATPase in discrete nephron segments microdissected from kidneys of adrenalectomized animals. Na-K-ATPase activity measured in proximal and distal nephron segments from adrenalectomized as well as intact mice remained unchanged 1 or 3 h after a single injection of D-aldosterone (10 micrograms/100 g body wt i.p.). Similarly, no effect of aldosterone could be demonstrated in experiments in vitro, in which tubules from adrenalectomized mice and rabbits were incubated (90 min, 37 degrees C) in the presence of physiologic or pharmacologic concentrations of the hormone (3.10(-10) to 3.10(-6) M). These studies did not show an effect of aldosterone on isolated tubule Na-K-ATPase within the time interval in which this hormone alters tubular cation transport and therefore do not support the “pump theory” of mineralocorticoid action. Copyright © 1981 the American Physiological Society
AJP - Renal Physiology – The American Physiological Society
Published: Sep 1, 1981
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.