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JENNIFER S. ELZ, WINIFRED G. NAYLER of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia MICHAEL J., JENNIFER S. ELZ, WINIFRED G. Sacrolemmal enzymes Naâ-Ca2â exchange in hypoxic, ischemic, reperfused rat hearts. Am. J. Physiol. 247 DALY, NAYLER. (Heart Circ. Physiol. 16): H237-H243, 1984.-Isolated spontaneously beating rat hearts were perfused in the Langendorff mode divided into four groups, i.e., control (aerobic), hypoxic (95% N,-5% C02), ischemic, ischemic reperfused. After a total of 90 min of perfusion, the isolated was enzymatically characterized. Ouabain-sensitive Na+-KâATPase wasinhibited in all three experimental groups,whereas K+-stimulated phosphataseactivity was decreased only in the ischemic reperfused groups compared with control. 5âNucleotidase activity was inhibited (P < 0.05) only in the ischemicgroup. Mg2â-ATPase activity was not different from control. PassiveCa2+uptake Ca2â efflux were not significantly altered by any of the interventions. Na+-Ca2+ exchange rate, but not capacity, wasdecreased 32-42%) in the ische(by mic group but this waspartially reversedon reperfusion. These results suggestthat changessecondary to lack of flow rather METHODS than O2play a major role in the etiology of ischemicdamage to Adult male Sprague-Dawley rats (200-275 g) were the membrane that a 15-min period of reperfusion after 60 anesthetized with a diethylether-O2 mixture heparinmin of ischemiadoesnot exacerbate
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Aug 1, 1984
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