METHODS Studies vitro. Mongrel dogs of either sex, weighg 7-15 kg, were anesthetized with travenous jections of pentobarbital sodium (30 mg/kg) killed by bleedg from the carotid arteries. The eyeballs attached with optic s extraocular tissues were isolated from the orbital cavities. Extraocular muscles were removed, the retal central arteries (0.3-0.4 mm OD) just before enterg to the eyeball were carefully isolated. The arteries were cut to helical strips of - 10 mm long, with care to preserve the endothelium. The specimens were vertically fixed between hooks a muscle bath contag the modified Rger-Locke solution that was mataed at 37 t_ 0.3âC aerated with a mixture of 95% 02- 5% COa. The hooks anchorg the upper end of the strips were connected to the lever of a force-displacement transducer. The restg tension was adjusted to 0.7 g, which is optimal of ducg the maximal contraction. The composition of the bathg medium was as follows ( mM): 120 NaCl, 5.4 KCl, 2.2 CaC12, 1.0 MgC12, 25.0 NaHC03, 5.6 dextrose. The pH of the solution was 7.35-7.42. Before the start of experiments, all of the strips were allowed to equilibrate for 60-90 m the bathg media, durg which time the
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: May 1, 1994
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