Role of nitric oxide in regulation of basilar artery tone in vivo

Role of nitric oxide in regulation of basilar artery tone in vivo artery tone in vivo FRANK M. FARACI Department of Internal Medicine, Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa 52242 FARACI, FRANK M. Role of in regulation of basilar artery tone in vivo. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1216-H1221, 1990.-Previous studies have suggested that (NO) may be a major endothelium-derived relaxing factor in peripheral blood vessels. This study tested the hypotheses that 1) formation of NO from L-arginine contributes to basal tone of arteries in vivo 2) dilator responses of arteries to acetylcholine are dependent on formation of NO. Diameter of the basilar artery was measured through a cranial window in anesthetized rats. Under control conditions, topical application of 10 PM NG-monomethyl-L-arginine (L-NMMA, an arginine analogue that inhibits enzymatic formation of NO), constricted the basilar artery by 11 - 1% (means - SE). L-Arginine + + (100 PM), which had no effect on baseline diameter, abolished vasoconstriction in response to L-NMMA. L-Arginine did not alter vasodilatation during acetylcholine (1 PM) (11 t 2 vs. 12 t 2%) or vasoconstriction during serotonin (1 nM) (-15 t 3 vs. -16 t 2%). LNMMA (5-10 ,uM) abolished the dilator response of the basilar artery to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Role of nitric oxide in regulation of basilar artery tone in vivo

AJP - Heart and Circulatory Physiology, Volume 259: H1216 – Oct 1, 1990

Loading next page...
 
/lp/the-american-physiological-society/role-of-nitric-oxide-in-regulation-of-basilar-artery-tone-in-vivo-6c7S3aeEkE
Publisher
The American Physiological Society
Copyright
Copyright © 1990 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

artery tone in vivo FRANK M. FARACI Department of Internal Medicine, Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa 52242 FARACI, FRANK M. Role of in regulation of basilar artery tone in vivo. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1216-H1221, 1990.-Previous studies have suggested that (NO) may be a major endothelium-derived relaxing factor in peripheral blood vessels. This study tested the hypotheses that 1) formation of NO from L-arginine contributes to basal tone of arteries in vivo 2) dilator responses of arteries to acetylcholine are dependent on formation of NO. Diameter of the basilar artery was measured through a cranial window in anesthetized rats. Under control conditions, topical application of 10 PM NG-monomethyl-L-arginine (L-NMMA, an arginine analogue that inhibits enzymatic formation of NO), constricted the basilar artery by 11 - 1% (means - SE). L-Arginine + + (100 PM), which had no effect on baseline diameter, abolished vasoconstriction in response to L-NMMA. L-Arginine did not alter vasodilatation during acetylcholine (1 PM) (11 t 2 vs. 12 t 2%) or vasoconstriction during serotonin (1 nM) (-15 t 3 vs. -16 t 2%). LNMMA (5-10 ,uM) abolished the dilator response of the basilar artery to

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Oct 1, 1990

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off