artery tone in vivo FRANK M. FARACI Department of Internal Medicine, Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa 52242 FARACI, FRANK M. Role of in regulation of basilar artery tone in vivo. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1216-H1221, 1990.-Previous studies have suggested that (NO) may be a major endothelium-derived relaxing factor in peripheral blood vessels. This study tested the hypotheses that 1) formation of NO from L-arginine contributes to basal tone of arteries in vivo 2) dilator responses of arteries to acetylcholine are dependent on formation of NO. Diameter of the basilar artery was measured through a cranial window in anesthetized rats. Under control conditions, topical application of 10 PM NG-monomethyl-L-arginine (L-NMMA, an arginine analogue that inhibits enzymatic formation of NO), constricted the basilar artery by 11 - 1% (means - SE). L-Arginine + + (100 PM), which had no effect on baseline diameter, abolished vasoconstriction in response to L-NMMA. L-Arginine did not alter vasodilatation during acetylcholine (1 PM) (11 t 2 vs. 12 t 2%) or vasoconstriction during serotonin (1 nM) (-15 t 3 vs. -16 t 2%). LNMMA (5-10 ,uM) abolished the dilator response of the basilar artery to
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Oct 1, 1990
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