The health-promoting effects of physical activity to prevent and treat metabolic disorders are numerous. However, the underlying molecular mechanisms are not yet completely deciphered. In recent years, studies have reported that the liver can be considered as a secretory organ by releasing specific proteins called hepatokines. Some of these hepatokines are involved in the whole-body metabolic homeostasis and participates in the development of metabolic diseases. In this regards, the present review describes the role of FGF21, Fetuin-A, Angiopoietin-like protein 4 and Follistatin in metabolic diseases and their production in response to acute exercise. Also, we discuss the potential of hepatokines in mediating the beneficial effect of regular exercise and the future challenge to discover new exercise-induced hepatokines.
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Oct 9, 2018
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