MEODS All protocols and surgical procedures employed in is study were reviewed and approved by e Institutional Animal Care and Use Committee of e University of New Mexico School of Medicine. Experiments were performed using conscious unrestrained male Sprague-Dawley rats (Harlan Industries) (272427 g body wt). Surgical Preparation involves a biphasic hemodynamic response in conscious mammals. e first phase, blood pressure is maintained due primarily to a reflex increase in total peripheral resistance (TPR) (30). However, as central blood volume falls below a critical point, a second phase develops at is characterized by widrawal of sympaetic tone to e vasculature, a precipitous drop in TPR, bradycardia, and an abrupt fall in arterial blood pressure. is second phase of is generally believed to be mediated by stimulation of cardiopulmonary receptors wi vagal afferents conditions of extreme ventricular underfill. Numerous studies support a role for endogenous opioids and serotonin in mediating e sympaoinhibition at ACUTE BLOOD LOSS 0363-6135/95 $3.00 Copyright o 1995 Animals designated for protocols were chronically instrumented wi pulsed Doppler blood flow probes for determination of cardiac output (CO) as previously described (28). Briefly, piezoelectric crystal assemblies (20 MHz, 1 mm diameter; Crystal Biotech) were placed in a
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Nov 1, 1995
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