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of Human in sympathetically AND W. H. M. SARIS 6200 MD Maastricht, The Netherlands M. A. VAN BAAK, K. P. G. KEMPEN, Biology, University of Limburg, Blaak, E. E., M. A. van Baak, K. P. G. Kempen, and W. H. M. Saris. Role of cy-and ,& in sympathet- ically mediated thermogenesis. Am. J. Physiol. 264 (Endocrinol. Metab. 27): Ell-El7,1993.-This study was intended to investigate the role of CY- ,&adrenoceptor populations in the symand pathetically mediated thermogenesis in healthy lean males. In the first study, the &-, &-, and &-agonist isoprenaline was infused in increasing doses with and without simultaneous infusion of the &-blocker atenolol (Iso and Iso + AT, respectively). There was an increase in whole body energy expenditure (EE) after infusing Iso + AT (P < 0.001) and an almost twofold higher increase after infusion of Iso only (P < 0.001). Stimulation of the P,- by a specific agonist (salbutamol) resulted in a significant increase in EE (P < 0.001). The effect of stimulation of a,- on EE was measured by infusing increasing doses of the q-agonist phenylephrine. EE did not change, whereas blood pressure (BP) increased (P < 0.001) and heart rate decreased (P < 0.01).
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Jan 1, 1993
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