Renin-angiotensin system: biochemistry and mechanisms of action

Renin-angiotensin system: biochemistry and mechanisms of action Vol. 57, No. 2, April 1977 Printed in U.SA. MICHAEL Department School J. PEACH of Pharmacology, University of Virginia of Medicine, Charlottesville, Virginia I. Introduction.. .......................................................... ...................................... II. Pathways for Formation of Peptides A. Renin ............................................................... B. Reninsubstrate ..................................................... C. Converting enzyme .................................................. D. Angiotensinases ..................................................... III. Actions of Angiotensin I ................................................. A. Nervoussystem ..................................................... B. Direct cardiovascular action .......................................... ............................................... C. Decapeptide analogues IV. Actions of Nonapeptides ................................................. V. Actions of Angiotensins II and III and Lower Homologues A. Cardiovascular system ............................................... B. Nervoussystems ..................................................... ...................................................... C. Adrenalcortex VI. Conclusions ............................................................ ................. I. INTRODUCTION The renin-angiotensin system is intricately involved in the homeostasis of peripheral vacular resistance as well as volume and electrolyte composition of body fluids (for reviews before 1966 see 63, 391, 413,474; after 1966 see 278, 359, 382, 392, 394, 425). Until recently, the proteolytic enzyme renin and the octapeptide angiotensin II (AII) have been the focal points for most studies that have addressed the physiologic and/or pathophysiologic significance of this complex system. Angiotensin II is a very potent peptide with a vast spectrum of biologic activities. Advances in metho ology for peptide synthesis and the demonstration of the receptor blocking properties of analogues http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physiological Reviews The American Physiological Society

Renin-angiotensin system: biochemistry and mechanisms of action

Physiological Reviews, Volume 57: 313 – Apr 1, 1977

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Publisher
The American Physiological Society
Copyright
Copyright © 1977 the American Physiological Society
ISSN
0031-9333
eISSN
1522-1210
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Abstract

Vol. 57, No. 2, April 1977 Printed in U.SA. MICHAEL Department School J. PEACH of Pharmacology, University of Virginia of Medicine, Charlottesville, Virginia I. Introduction.. .......................................................... ...................................... II. Pathways for Formation of Peptides A. Renin ............................................................... B. Reninsubstrate ..................................................... C. Converting enzyme .................................................. D. Angiotensinases ..................................................... III. Actions of Angiotensin I ................................................. A. Nervoussystem ..................................................... B. Direct cardiovascular action .......................................... ............................................... C. Decapeptide analogues IV. Actions of Nonapeptides ................................................. V. Actions of Angiotensins II and III and Lower Homologues A. Cardiovascular system ............................................... B. Nervoussystems ..................................................... ...................................................... C. Adrenalcortex VI. Conclusions ............................................................ ................. I. INTRODUCTION The renin-angiotensin system is intricately involved in the homeostasis of peripheral vacular resistance as well as volume and electrolyte composition of body fluids (for reviews before 1966 see 63, 391, 413,474; after 1966 see 278, 359, 382, 392, 394, 425). Until recently, the proteolytic enzyme renin and the octapeptide angiotensin II (AII) have been the focal points for most studies that have addressed the physiologic and/or pathophysiologic significance of this complex system. Angiotensin II is a very potent peptide with a vast spectrum of biologic activities. Advances in metho ology for peptide synthesis and the demonstration of the receptor blocking properties of analogues

Journal

Physiological ReviewsThe American Physiological Society

Published: Apr 1, 1977

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