Reliability of error estimates from the minimal model: implications for measurements in physiological studies

Reliability of error estimates from the minimal model: implications for measurements in... Prigeon, Ronald L., Steven E. Kahn, and Daniel Porte, Jr. of error estimates from the : implications for measurements in physiological studies. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E279-E286, 1994.-MINMOD provides an estimate error in the insulin sensitivity index (SI) and glucose effectiveness at basal insulin (Sg) as the fractional standard deviation (FSD). The validity FSD estimate has not been assessed in a large number of human studies, nor has a comparison accuracies achievable using the two different intravenous glucose tolerance test (IVGTT) protocols (glucose only and tolbutamide protocol) been performed. To address these two issues, we obtained the FSD value and performed Monte Carlo simulations for 237 IVGTT studies. The FSD underestimated the true error as determined as the coefficient of variation from Monte Carlo simulation (COV-MC) with the ratio of COV-MC to FSD being 3.07 t 0.20 (mean t SE) for Si using the tolbutamide protocol. Additionally, the mean COV-MC for glucose-only protocol was approximately two to three times that for the tolbutamide protocol for both SI and Sg. We conclude that FSD underestimates the true error in SI and Sg. Additionally, more accurate results are obtained from the tolbutamide protocol than with the glucose-only http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Reliability of error estimates from the minimal model: implications for measurements in physiological studies

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Publisher
The American Physiological Society
Copyright
Copyright © 1994 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
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Abstract

Prigeon, Ronald L., Steven E. Kahn, and Daniel Porte, Jr. of error estimates from the : implications for measurements in physiological studies. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E279-E286, 1994.-MINMOD provides an estimate error in the insulin sensitivity index (SI) and glucose effectiveness at basal insulin (Sg) as the fractional standard deviation (FSD). The validity FSD estimate has not been assessed in a large number of human studies, nor has a comparison accuracies achievable using the two different intravenous glucose tolerance test (IVGTT) protocols (glucose only and tolbutamide protocol) been performed. To address these two issues, we obtained the FSD value and performed Monte Carlo simulations for 237 IVGTT studies. The FSD underestimated the true error as determined as the coefficient of variation from Monte Carlo simulation (COV-MC) with the ratio of COV-MC to FSD being 3.07 t 0.20 (mean t SE) for Si using the tolbutamide protocol. Additionally, the mean COV-MC for glucose-only protocol was approximately two to three times that for the tolbutamide protocol for both SI and Sg. We conclude that FSD underestimates the true error in SI and Sg. Additionally, more accurate results are obtained from the tolbutamide protocol than with the glucose-only

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Feb 1, 1994

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