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AND TOSHIAKI TACHIBANA School of Medicine, Tokyo 105, Japan pituitary gland of rats. The experiments were designed to answer the following questions: 1) Does thyroid hormone exert a stimulatory effect on in the pituitary gland? 2) If so, at what stage does this became evident? 3) Is the elevation of thyroid hormone level relevant to the rapid maturation of cells, which takes place between days 18 and 19 of gestation? MATERIALS AND METHODS Nogami, Haruo, Takashi Yokose, and Toshiaki Tachibana. Regulation of growth hormone in rat pituitary gland by thyroid or glucocorticoid hormone. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E262-E267, 1995.-The regulation of growth hormone () cell development by thyroid and glucocorticoid hormones in the rat pituitary gland was examined. Dexamethasone (Dex) treatment of dams induced and mRNA accumulation in the pituitary gland on day 17 or 18 of gestation when substantial has not yet occurred in the control fetus. The additional thyroxine injections apparently enhanced the effect of Dex, whereas it exhibited no effect when given alone. The reduction of thyroid hormone level by methimazole suppressed either the Dex induction of on day 18 or the spontaneous onset of on day 19 of gestation. The results
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Feb 1, 1995
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