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Reduced chronotropic responsiveness of the heart in experimental uremia

KARL H. JAKOBS, University JOHANNES RIEDEL, Departments of Medice and Pharmacology, 69 Heidelberg, Federal Republic of Germany of Heidelberg, DEL, AND EBERHARD RITZ. Reduced chronotropic of the heart experimental . Am J. Physiol. 250 (Heart Circ. Physiol. 19): H846-H852, 1986.-Cardiac P-adrenoceptor evaluated experimental was by vivo and vitro techniques. was duced rats by bilateral nephrectomy for 48 h. 1) rats with chronic tra- MANN, J~HANNES F. E., KARL H. JAKOBS, JOHANNES RIE- arterial and travenous catheters, cardiovascular reflexes and the ren-angiotens system were blocked with atrope, pentolium, and a convertg-enzyme hibitor, respectively. Blood pressure(BP) and heart rate (HR) were contuously recorded. Cumulative dosesof isoproterenol were jected travenously. uremic rats, the dose-response curve for the HR response showeda lower maximal response(P < 0.01) and no significant difference 50% effective dosevalues compared with controls, whereasthe BP decrease caused isoproterenol by wassimilar control and uremic rats. 2) When forskol was jected travenously to stimulate adenylate cyclase a receptor-dependent manner, the maximal HR crease was lower uremic rats (P c 0.01). 3) ,&Adrenoceptor density and affity, measured ‘*“I-cyanopdolol bdg to sarcolemmal by membranes, not different betweencontrol and uremic rats, was Also bdg affities for the agonist isoproterenol were not different between groups. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

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