CHRISTIANE ROUYER-FESSARD, AND dicatg that teste is a site of synthesis (19). human fetus, -mRNAs have been localized the testal lama propria, whereas immunoreactive s are detectable close proximity of epithelial cells (11). This is consonance with observations dicatg that somatomeds, although traditionally considered to origate the liver, are synthesized at multiple sites the body and may have a paracre mechanism of action (4, 11, 19). Third, growth hormone has been implicated as a trophic factor gastrotestal tissue (13), supportg a role for -I because this growth factor is most probably the long-sought somatomed that mediates the growth effects of growth hormone (12). that would be expected to mediate growth effects of s gastrotestal epithelial cells, have not yet been identified. the present paper, we show that rat gastrotestal is equipped with two sets of that recognize preferentially either -I or -II. These appear to be more abundant proliferative crypt cells than mature villus cells from small teste. METHODS SUL-LIKE GROWTH FACTORS (s) I and II are peptides structurally homologous with prosul (12) that stimulate growth and metabolic effects a variety of cells through teraction with specific (21, 23, 26). The gastrotestal mucosa has one of the most
AJP - Gastrointestinal and Liver Physiology – The American Physiological Society
Published: Mar 1, 1988
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