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S. Starnes, B. Duncan, J. Kneebone, C. Fraga, S. States, G. Rosenthal, F. Lupinetti (2000)
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Tumor angiogenesis in human lung adenocarcinoma
Abstract We developed a rat model of pulmonary arteriovenous malformations after cavopulmonary anastomosis. We sought to determine whether this model reproduces the angiographic and histologic features seen in the human condition. Eight Sprague-Dawley rats underwent a right superior cavopulmonary anastomosis with the use of microsurgical techniques. Between 2 and 13 mo, pulmonary angiography was performed, the animals were euthanized, and the lungs were removed. Microscopic sections of the lung were stained with an endothelial-specific antibody (von Willebrand factor). Microvessel density was determined by counting vessels staining positively for von Willebrand factor, and the shunted and nonshunted (control) lungs were compared for each animal. Pulmonary angiography revealed time-dependent development of arteriovenous malformations. Microvessel density demonstrated a time-dependent increase in the shunted lung compared with the control lung (simple linear regression of the ratio of the microvessel density of the shunted lung divided by the microvessel density of the control lung on time; R 2 = 0.79, P = 0.003). This animal model reproduces the same angiographic and microscopic features of pulmonary arteriovenous malformations that develop in humans after cavopulmonary anastomosis. This appears to be a valid model that may be used to further study etiologic mechanisms for this phenomenon. congenital heart surgery cavopulmonary anastomosis Footnotes Address for reprint requests and other correspondence: B. W. Duncan, Pediatric and Congenital Heart Surgery, Cleveland Clinic Foundation M/41, 9500 Euclid Ave., Cleveland, OH 44195 (E-mail: duncanb@ccf.org ). The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “ advertisement ” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. July 11, 2002;10.1152/ajpheart.00368.2002 Copyright © 2002 the American Physiological Society
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Nov 1, 2002
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