PROPAGATION OF SPREADING CORTICAL DEPRESSION

PROPAGATION OF SPREADING CORTICAL DEPRESSION LEKO Harvard for of Anatomy, (Received R. Medical S. MORISON School, Boston, October 25, 1944) Massachusetts publication PREVIOUS STUDIES on rabbits cats (4, 5) have shown that moderate tetanic stimulation of the cortex results in a of the recordable electrical activity which spreads slowly in all directions passes off in from five to ten minutes. It is accompanied by dilatation of the pial arteries, capillaries, veins more notable even than that produced by the inhalation of large quantities of carbon dioxide. The unusual nature of the phenomenon plus the fact that several features suggest its similarity to the spread of the process underlying epileptiform discharges appeared to warrant further investigation. The following studies were directed primarily toward determining whether a slowly conducted neuron to neuron “inhibition” could account for the data. METHODS Rabbits under dial anesthesia (0.65 cc. per kg.) were used throughout, this species being selected because it has a relatively large non-convoluted cortex which exhibits the phenomenon in a striking readily repeatable manner for hours on end. Recording electrodes, amplifiers oscillographs were similar to those employed in previous studies. Stimulating pulses were supplied by a thyratron feeding through a transformer arranged with a Wagner ground in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

PROPAGATION OF SPREADING CORTICAL DEPRESSION

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Publisher
The American Physiological Society
Copyright
Copyright © 1945 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
Publisher site
See Article on Publisher Site

Abstract

LEKO Harvard for of Anatomy, (Received R. Medical S. MORISON School, Boston, October 25, 1944) Massachusetts publication PREVIOUS STUDIES on rabbits cats (4, 5) have shown that moderate tetanic stimulation of the cortex results in a of the recordable electrical activity which spreads slowly in all directions passes off in from five to ten minutes. It is accompanied by dilatation of the pial arteries, capillaries, veins more notable even than that produced by the inhalation of large quantities of carbon dioxide. The unusual nature of the phenomenon plus the fact that several features suggest its similarity to the spread of the process underlying epileptiform discharges appeared to warrant further investigation. The following studies were directed primarily toward determining whether a slowly conducted neuron to neuron “inhibition” could account for the data. METHODS Rabbits under dial anesthesia (0.65 cc. per kg.) were used throughout, this species being selected because it has a relatively large non-convoluted cortex which exhibits the phenomenon in a striking readily repeatable manner for hours on end. Recording electrodes, amplifiers oscillographs were similar to those employed in previous studies. Stimulating pulses were supplied by a thyratron feeding through a transformer arranged with a Wagner ground in

Journal

Journal of NeurophysiologyThe American Physiological Society

Published: Jan 1, 1945

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