CORINNA-B. STEEB, JEFFREY F. TRAHAIR, FRANK M. Cooperative Research Center for Tissue Growth and Repair, North Adelaide, South Australia 5006; and Commonwealth Organization, Division of Human Nutrition, Adelaide, South Steeb, Corinna-B., Jeffrey F. Trahair, Frank M. Tomas, and Leanna C. Read. Prolonged administration of IGF peptides enhances growth of gastrointestinal tissues in normal rats. Am. J. Physiol. 266 (Gastrointest. Liver PhysioZ. 29): Gl090-G1098,1994.-To investigate the effect of growth (IGF) peptide infusion on the gastrointestinal tract, female rats (115 g, G/group) were treated for 14 days with IGF-I or long R (LRâIGF-I; 0, 44, 111, or 278 pg/day) delivered by osmotic minipumps. Both peptides induced a dose-dependent increase in gastrointestinal tissue weight. Total weight, small intestinal weight, and small intestinal length increased by 43, 47, and 13%, respectively, after treatment with 278 pg/day of LR31GF-I. Crypt depth and villus height increased after peptide treatment with an associated increased crypt cell population (+33%), cells per villus column (+ 34%), and villus cell density (+ 20%). Proportional increments in proliferating cell nuclear antigen labeling and an unaltered crypt growth fraction indicated that the balance between the proliferative and maturation compartment of the crypt was maintained. Fecal nitrogen excretion was significantly reduced
AJP - Gastrointestinal and Liver Physiology – The American Physiological Society
Published: Jun 1, 1994
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