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Prolongation of inspiration during lower airway occlusion in children

Prolongation of inspiration during lower airway occlusion in children Hering-Breuer reflex; mechanoreceptors; diaphragm (13) and Breuer (5) that anesthetized animals had a lung volumerelated inhibition which could be abolished by vagotomy. This reflex has since been described in many mammalian species (4, 7, 11, 26) and is felt to play a role in the regulation of breathing in these animals. The activity and clinical significance of this inspiration inhibitory reflex in humans is less well defined. Although volume-related inhibition has been shown in anesthetized humans (22), it does not appear to play a physiological role normal, spontaneous breathing in adults (7, 26). Different techniques have been used to study the Hering-Breuer reflex in human newborns, making the resultant observations difficult to interpret and compare. Using apnea duration after lung inflation as an index of the Hering-Breuer reflex, Cross et al. (8) and Bodegard et al. (2) showed that, in term and preterm neonates, reflex activity diminished with advancing postnatal age. Subsequently, Younes et al. (27) showed that in cats the duration of apnea following lung inflation is dependent on chemical as well as mechanical factors, thus challengin 1868 1860 0161-7567/87 $1.50 Copyright IT WAS DEMONSTRATED by Hering ing the validity of this method in quantitating HeringBreuer reflex http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Prolongation of inspiration during lower airway occlusion in children

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Publisher
The American Physiological Society
Copyright
Copyright © 1987 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
See Article on Publisher Site

Abstract

Hering-Breuer reflex; mechanoreceptors; diaphragm (13) and Breuer (5) that anesthetized animals had a lung volumerelated inhibition which could be abolished by vagotomy. This reflex has since been described in many mammalian species (4, 7, 11, 26) and is felt to play a role in the regulation of breathing in these animals. The activity and clinical significance of this inspiration inhibitory reflex in humans is less well defined. Although volume-related inhibition has been shown in anesthetized humans (22), it does not appear to play a physiological role normal, spontaneous breathing in adults (7, 26). Different techniques have been used to study the Hering-Breuer reflex in human newborns, making the resultant observations difficult to interpret and compare. Using apnea duration after lung inflation as an index of the Hering-Breuer reflex, Cross et al. (8) and Bodegard et al. (2) showed that, in term and preterm neonates, reflex activity diminished with advancing postnatal age. Subsequently, Younes et al. (27) showed that in cats the duration of apnea following lung inflation is dependent on chemical as well as mechanical factors, thus challengin 1868 1860 0161-7567/87 $1.50 Copyright IT WAS DEMONSTRATED by Hering ing the validity of this method in quantitating HeringBreuer reflex

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: May 1, 1987

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