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PRESENT VIEWS ON THE MODE OF ACTION OF ACETYLCHOLINE IN THE CENTRAL NERVOUS SYSTEM

PRESENT VIEWS ON THE MODE OF ACTION OF ACETYLCHOLINE IN THE CENTRAL NERVOUS SYSTEM OF ACTION OF ACETYLCHOLINE NERVOUS SYSTEM The Ph.ysiological Laboratory, Cambridge The conception that acetylcholine acts as chemical transmitter in the central nervous system is a logical extension of the theory of chemical transmission by acetylcholine across ganglionic synapses and from motor nerve endings to the motor endplates of skeletal muscles. About ten years ago Dale (1934), when discussing the evidence for the transmission by acetylcholine across ganglionic synapses, pointed out that this theory involved a much wider aspect, viz.? aI similar transmission at central synapses. A few years later, in his Harvey Lectures (1936/37), he took up the problem again. He drew attention to the fact that Eccles had used the sympathetic ganglion “as furnishing an accessible model of the synapses of the central grey matter” an.d that Sherrington had looked upon the transmission at a motor endplate “as probably furnishing aI It is fhcs not: pattern, or paradigm, of what happened at a central synapse." surprising t#hat the methods of investigation used for the gq$ion and for volunt,ary muscle should be extended to the central nervous system. The following three lines of research have supplied the main evidence on which the acetylcholine theory in the peripheral nervous http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physiological Reviews The American Physiological Society

PRESENT VIEWS ON THE MODE OF ACTION OF ACETYLCHOLINE IN THE CENTRAL NERVOUS SYSTEM

W. Feldberg
Physiological Reviews , Volume 25: 596 – Oct 1, 1945
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Publisher
The American Physiological Society
Copyright
Copyright © 1945 the American Physiological Society
ISSN
0031-9333
eISSN
1522-1210
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Abstract

OF ACTION OF ACETYLCHOLINE NERVOUS SYSTEM The Ph.ysiological Laboratory, Cambridge The conception that acetylcholine acts as chemical transmitter in the central nervous system is a logical extension of the theory of chemical transmission by acetylcholine across ganglionic synapses and from motor nerve endings to the motor endplates of skeletal muscles. About ten years ago Dale (1934), when discussing the evidence for the transmission by acetylcholine across ganglionic synapses, pointed out that this theory involved a much wider aspect, viz.? aI similar transmission at central synapses. A few years later, in his Harvey Lectures (1936/37), he took up the problem again. He drew attention to the fact that Eccles had used the sympathetic ganglion “as furnishing an accessible model of the synapses of the central grey matter” an.d that Sherrington had looked upon the transmission at a motor endplate “as probably furnishing aI It is fhcs not: pattern, or paradigm, of what happened at a central synapse." surprising t#hat the methods of investigation used for the gq$ion and for volunt,ary muscle should be extended to the central nervous system. The following three lines of research have supplied the main evidence on which the acetylcholine theory in the peripheral nervous

Journal

Physiological Reviews – The American Physiological Society

Published: Oct 1, 1945

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