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Pre- and postjunctional effects of a thromboxane mimetic in canine bronchi

Pre- and postjunctional effects of a thromboxane mimetic in canine bronchi L. J. JANSSEN AND E. E. DANIEL Department of Biomedical Sciences, McMaster University, Hamilt, tario L8N 325, Canada JANSSEN, L. J., AND E. E. DANIEL. Pre- and postjunctial of a thromboxane mimetic in . Am. J. Physiol. 261 (Lung Cell. Mol. Physiol. 5): L271-L276, 1991.Thromboxane A, is believed to participate in causati of hyperreactivity of airway smooth muscle (ASM). We therefore investigated the of a thromboxane mimetic (U6619) isolated ring segments of al ASM (3rd to 5th order). U6619 (lo-“-lo-” M) was found to elicit tic ctracti, membrane depolarizati, and oscillatis in membrane potential. These were sensitive to blockade of thromboxane receptors (using lo-” M L 670,596); the mechanical respse was insensitive to 3 x 10s8 M atropine, 10d7 M nitrendipine, or exposure to Ca’+-free media [(ctaining 0.5 mM ethylene glycol-bis(P-aminoethyl ether)-N,N,N’,N’-tetraacetic acid (EGTA)]. U6619 also potentiated electrical field stimulati-elicited ctractis and excitatory juncti potentials without altering the sensitivity to carbachol. This potentiati was also sensitive to L 670,596 but not to blockade of adrenoceptors (using phentolamine plus propanolol). We cclude that al ASM possesses both prejunctial and postjunctial thromboxane receptors. The former potentiate cholinergic neurotransmissi through a mechanism not involving adrenoceptors. The latter excite the ASM through http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Lung Cellular and Molecular Physiology The American Physiological Society

Pre- and postjunctional effects of a thromboxane mimetic in canine bronchi

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Publisher
The American Physiological Society
Copyright
Copyright © 1991 the American Physiological Society
ISSN
1040-0605
eISSN
1522-1504
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Abstract

L. J. JANSSEN AND E. E. DANIEL Department of Biomedical Sciences, McMaster University, Hamilt, tario L8N 325, Canada JANSSEN, L. J., AND E. E. DANIEL. Pre- and postjunctial of a thromboxane mimetic in . Am. J. Physiol. 261 (Lung Cell. Mol. Physiol. 5): L271-L276, 1991.Thromboxane A, is believed to participate in causati of hyperreactivity of airway smooth muscle (ASM). We therefore investigated the of a thromboxane mimetic (U6619) isolated ring segments of al ASM (3rd to 5th order). U6619 (lo-“-lo-” M) was found to elicit tic ctracti, membrane depolarizati, and oscillatis in membrane potential. These were sensitive to blockade of thromboxane receptors (using lo-” M L 670,596); the mechanical respse was insensitive to 3 x 10s8 M atropine, 10d7 M nitrendipine, or exposure to Ca’+-free media [(ctaining 0.5 mM ethylene glycol-bis(P-aminoethyl ether)-N,N,N’,N’-tetraacetic acid (EGTA)]. U6619 also potentiated electrical field stimulati-elicited ctractis and excitatory juncti potentials without altering the sensitivity to carbachol. This potentiati was also sensitive to L 670,596 but not to blockade of adrenoceptors (using phentolamine plus propanolol). We cclude that al ASM possesses both prejunctial and postjunctial thromboxane receptors. The former potentiate cholinergic neurotransmissi through a mechanism not involving adrenoceptors. The latter excite the ASM through

Journal

AJP - Lung Cellular and Molecular Physiology – The American Physiological Society

Published: Oct 1, 1991

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