Postexercise dose-response relationship between plasma glucose and insulin secretion

Postexercise dose-response relationship between plasma glucose and insulin secretion IN HUMANS, plasma insulin concentrations are reduced during exercise (12), and low insulin values can persist for long periods after exercise (7). This could be a consequence of a changed glucose sensitivity of the ,&cell developed during exercise. A decrease in glucose sensitivity of the ,&cell after exercise would be reasonable in light of the fact that the sensitivity of tissue glucose uptake to insulin is increased at least 48 h after exercise (29). The effect of exercise on pancreatic ,&-cell function has previously been investigated by oral or intravenous glucose tolerance tests. In accordance with a decrease in glucose sensitivity of the ,&cell, plasma insulin concen0161-7X7/88 $1.50 Copyright trations are lower during oral glucose tolerance tests when tests are performed after exercise than when performed after rest (21). However, rather than affecting an adaptation of the P-cell, this could be due to a decreased glucose-induced release of incretin by intragastric glucose after exercise (2). Furthermore, glucose tolerance tests are difficult to interpret, since they represent nonsteady-state tests and since, furthermore, results are influenced not only by insulin secretion, but also by insulin clearance, insulin sensitivity, distribution spaces for insulin and glucose, and absorption capacity for orally administered http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Postexercise dose-response relationship between plasma glucose and insulin secretion

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Publisher
The American Physiological Society
Copyright
Copyright © 1988 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
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Abstract

IN HUMANS, plasma insulin concentrations are reduced during exercise (12), and low insulin values can persist for long periods after exercise (7). This could be a consequence of a changed glucose sensitivity of the ,&cell developed during exercise. A decrease in glucose sensitivity of the ,&cell after exercise would be reasonable in light of the fact that the sensitivity of tissue glucose uptake to insulin is increased at least 48 h after exercise (29). The effect of exercise on pancreatic ,&-cell function has previously been investigated by oral or intravenous glucose tolerance tests. In accordance with a decrease in glucose sensitivity of the ,&cell, plasma insulin concen0161-7X7/88 $1.50 Copyright trations are lower during oral glucose tolerance tests when tests are performed after exercise than when performed after rest (21). However, rather than affecting an adaptation of the P-cell, this could be due to a decreased glucose-induced release of incretin by intragastric glucose after exercise (2). Furthermore, glucose tolerance tests are difficult to interpret, since they represent nonsteady-state tests and since, furthermore, results are influenced not only by insulin secretion, but also by insulin clearance, insulin sensitivity, distribution spaces for insulin and glucose, and absorption capacity for orally administered

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: Mar 1, 1988

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