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Platelet-derived growth factor stimulated mechanisms of glucosamine incorporation

Platelet-derived growth factor stimulated mechanisms of glucosamine incorporation CELLULAR EVENTS in the Go/G1 phase of the cell cycle regulate the rate of cellular proliferation. Traverse of density-arrested mouse embryo fibroblasts through Go/G1 is mediated by multiple serum-derived polypeptide growth factors with sequential or interdependent actions. Platelet-derived growth factor (PDGF) and other known competence factors (26) initiate a proliferative response in density-arrested BALB/c-3T3 cells. PDGF-treated cells are programmed to respond to progression activity or factors in platelet-poor plasma (PPP) that are required for Go/G1 traverse and entry into S phase. The competence-progression cell-cycle model provides a means for identifying cellular events required for and/or expressed as a function of initiation of cell growth, as well as those expressed during G1 traverse and entry into S phase. Several specific biochemical changes have been correlated with competence formation in density-arrested BALB/c-3T3 cells. In addition to specific cellular responses, several more general biosynthetic processes are required for cell-cycle traverse. Both and RNA SPECIFIC synthesis are necessary for competence formation and traverse of the first 6 h of G1, whereas only synthesis is necessary for the last 6 h of G, (29). There is also evidence to suggest that is required for cell-cycle traverse. Tunicamycin, an inhibitor of N-linked , has http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

Platelet-derived growth factor stimulated mechanisms of glucosamine incorporation

M. A. Harrington and W. J. Pledger
AJP - Cell Physiology , Volume 253: C567 – Oct 1, 1987
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Publisher
The American Physiological Society
Copyright
Copyright © 1987 the American Physiological Society
ISSN
0363-6143
eISSN
1522-1563
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Abstract

CELLULAR EVENTS in the Go/G1 phase of the cell cycle regulate the rate of cellular proliferation. Traverse of density-arrested mouse embryo fibroblasts through Go/G1 is mediated by multiple serum-derived polypeptide growth factors with sequential or interdependent actions. Platelet-derived growth factor (PDGF) and other known competence factors (26) initiate a proliferative response in density-arrested BALB/c-3T3 cells. PDGF-treated cells are programmed to respond to progression activity or factors in platelet-poor plasma (PPP) that are required for Go/G1 traverse and entry into S phase. The competence-progression cell-cycle model provides a means for identifying cellular events required for and/or expressed as a function of initiation of cell growth, as well as those expressed during G1 traverse and entry into S phase. Several specific biochemical changes have been correlated with competence formation in density-arrested BALB/c-3T3 cells. In addition to specific cellular responses, several more general biosynthetic processes are required for cell-cycle traverse. Both and RNA SPECIFIC synthesis are necessary for competence formation and traverse of the first 6 h of G1, whereas only synthesis is necessary for the last 6 h of G, (29). There is also evidence to suggest that is required for cell-cycle traverse. Tunicamycin, an inhibitor of N-linked , has

Journal

AJP - Cell Physiology – The American Physiological Society

Published: Oct 1, 1987

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