Oak Ridge Associated Universities, Oak Ridge, Tennessee 37831-0117 SNYDER, FRED. Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. Am. J. Physiol. 259 (Cell Physiol. 28): C697C708, 1990.-Platelet-activating factor (PAF or 1-alkyl-2acetyl-sn-glycero-3-phosphocholine) is the most potent lipid mediator yet discovered. It is known to stimulate a wide span of biological responses ranging from aggregation and degranulation of platelets and neutrophils to a variety of cellular effects involving the stimulation of chemotaxis; chemokinesis; superoxide formation; protein phosphorylation; activation of protein kinase C, arachidonic acid, and phosphoinositide metabolites; glycogenolysis; and tumor necrosis factor production. Obviously, with such a diversity of biological activities, it is not surprising that PAF has been considered to be a key component in numerous diseases related to hypersensitivity and inflammatory responses. Evidence has also been presented for the role of PAF in physiological processes, particularly those involving reproduction and fetal development. Furthermore, because of its potent hypotensive action, PAF has been implicated as a contributing factor in blood pressure regulation. PAF is produced by two independent enzymatic pathways. The remodeling route involves the structural modification of a membrane lipid (1-alkyl-2-acyl -sn-glycero-3-phosphocholine) bY replacement of the acyl moiety with an acetate group. An alternate
AJP - Cell Physiology – The American Physiological Society
Published: Nov 1, 1990
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