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Plasma norepinephrine in humans: limitations in assessment of whole body norepinephrine kinetics and plasma clearance

Plasma norepinephrine in humans: limitations in assessment of whole body norepinephrine kinetics... MATERIALS AND METHODS THESYMPATHETICNERVOUS SYSTEM isoneofthemajor pathways mediatg physiological responses to different organs and tissues the body. The sympathetic neurotransmitter (NE) leaks from the synaptic cleft to the blood stream, where its concentration reflects its neurotransmitter function (3). Because a vascular area may release as well as remove NE, quantification of NE- demands a method that can distguish both fluxes (10). Tritium-labeled L- ( [3H]NE) has provided a valuable tool for such studies (11, 20). Shorter travenous fusions of [3H]NE by Goldste et al. (12) and longer fusions by Esler et al. (9) have revealed equal and short itial plasma halflives. However, by comparg their reports (9, 12) we have observed that their plasma decay curves had different shapes. The present study was, therefore, undertaken 0193-1849/89 $1.50 Copyright Six normal volunteers were studied, five men and one woman. Their ages ranged from 28 to 40 yr. All volunteers consented to participate the followg vestigations after thorough oral and written explanation. The study was approved by the Ethics Committee for Medical Research Copenhagen, and no complications or side effects were seen durg or after the vestigative procedure. Protocol. Constant travenous fusions of [3H]NE1311-hippurate or [3H]IP-131I-hippurate were mataed supe s http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Plasma norepinephrine in humans: limitations in assessment of whole body norepinephrine kinetics and plasma clearance

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Publisher
The American Physiological Society
Copyright
Copyright © 1989 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
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Abstract

MATERIALS AND METHODS THESYMPATHETICNERVOUS SYSTEM isoneofthemajor pathways mediatg physiological responses to different organs and tissues the body. The sympathetic neurotransmitter (NE) leaks from the synaptic cleft to the blood stream, where its concentration reflects its neurotransmitter function (3). Because a vascular area may release as well as remove NE, quantification of NE- demands a method that can distguish both fluxes (10). Tritium-labeled L- ( [3H]NE) has provided a valuable tool for such studies (11, 20). Shorter travenous fusions of [3H]NE by Goldste et al. (12) and longer fusions by Esler et al. (9) have revealed equal and short itial plasma halflives. However, by comparg their reports (9, 12) we have observed that their plasma decay curves had different shapes. The present study was, therefore, undertaken 0193-1849/89 $1.50 Copyright Six normal volunteers were studied, five men and one woman. Their ages ranged from 28 to 40 yr. All volunteers consented to participate the followg vestigations after thorough oral and written explanation. The study was approved by the Ethics Committee for Medical Research Copenhagen, and no complications or side effects were seen durg or after the vestigative procedure. Protocol. Constant travenous fusions of [3H]NE1311-hippurate or [3H]IP-131I-hippurate were mataed supe s

Journal

AJP - Endocrinology and Metabolism – The American Physiological Society

Published: Nov 1, 1989

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