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E584-E590, 1986.-In the, present study hepatic esis by the direct versus indirect pathway was determined as a function of the glucoseinfusion . was examined in catheterized consciousrats that had been fasted 48 h before receiving a 3-h infusion (iv) of glucose.Glucose, containing tracer quantities of [U-ââCl- and [6-3H]glucose,was infused at s ranging from 0 to 230pmol mine1 kg-â. Plasma concentrations of glucose,lactate, and insulin were positively correlated with the glucoseinfusion . Despite large changes in plasmaglucose,lactate, and insulin concentrations, the of hepatic deposition (0.46 t 0.03 pmol*min-l. g-l) did not vary significantly between glucoseinfusion s of 20 and 230 pmol=min-â . kg? However, the percent contribution of the direct pathway to repletion gradually increased from 13 t 2 to 74 & 4% in the lowest to the highest glucose infusion s, with prevailing plasma glucoseconcentrations from 9.4 & 0.5 to 21.5 t 2.1 mM. Endogenousglucoseproduction was depressed up to 40%), but not abolishedby the (by glucoseinfusions. Only a small fraction (7-14%) of the infused glucoseload wasincorpod into liver via the direct pathway irrespective of the glucose infusion . Our data indicate that the relative contribution of the direct and indirect pathways of hepatic are dependent on the glucose
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Nov 1, 1986
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