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Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis

Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide... Castillo, L., M. SQnchez, J. Vogt, T. E. Chapman, T. C. DeRojas-Walker, S. R. Tannenbaum, A. M. Ajami, V. R. Young. Plasma , citrulline, ornithine kinetics in adults, with observations on . Am. J. Physiol. 268 (Endocrinol. Metab. 31): E360-E367, 1995.-The plasma fluxes of ornithine (Orn), (Arg), citrulline (Cit) rate of conversion of labeled ornithineto-citrulline (Qorn + tit) were estimated in six healthy adult men receiving an -rich or -free L-amino acidbased diet, each for 6 days. On day 7 an 8-h (3-h fast, 5-h fed) primed continuous intravenous infusion of L-[guanido15N,15N] , L-[ureido- 13C]citrulline, L-[5,5,2H2]ornithine, L-[5,5,5-2H3]leucine was conducted. Mean citrulline fluxes (pmol. kg-l. h-l) were 10.4-13.6 for the various conditions /or diets remained unchanged (P > 0.05). flux was lowered (P < 0.01) by 38% for fed state during -free period. Ornithine fluxes for -rich were (P < 0.01) reduced with the -free diet. Rates of Qorn+cit declined by 30% (P < .05) during the fed -free period. Short-term restriction in the dietary supply of did not alter the rate of whole body . One subject showed a very high output of nitrate on -free diet (6 times average for remaining subjects). nitrate; ity 15N-labeling; flux; homeostasis; http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis

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Publisher
The American Physiological Society
Copyright
Copyright © 1995 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
See Article on Publisher Site

Abstract

Castillo, L., M. SQnchez, J. Vogt, T. E. Chapman, T. C. DeRojas-Walker, S. R. Tannenbaum, A. M. Ajami, V. R. Young. Plasma , citrulline, ornithine kinetics in adults, with observations on . Am. J. Physiol. 268 (Endocrinol. Metab. 31): E360-E367, 1995.-The plasma fluxes of ornithine (Orn), (Arg), citrulline (Cit) rate of conversion of labeled ornithineto-citrulline (Qorn + tit) were estimated in six healthy adult men receiving an -rich or -free L-amino acidbased diet, each for 6 days. On day 7 an 8-h (3-h fast, 5-h fed) primed continuous intravenous infusion of L-[guanido15N,15N] , L-[ureido- 13C]citrulline, L-[5,5,2H2]ornithine, L-[5,5,5-2H3]leucine was conducted. Mean citrulline fluxes (pmol. kg-l. h-l) were 10.4-13.6 for the various conditions /or diets remained unchanged (P > 0.05). flux was lowered (P < 0.01) by 38% for fed state during -free period. Ornithine fluxes for -rich were (P < 0.01) reduced with the -free diet. Rates of Qorn+cit declined by 30% (P < .05) during the fed -free period. Short-term restriction in the dietary supply of did not alter the rate of whole body . One subject showed a very high output of nitrate on -free diet (6 times average for remaining subjects). nitrate; ity 15N-labeling; flux; homeostasis;

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Feb 1, 1995

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