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RALL B. SUSAN LENA GIACOMO Division of Perinatal Medicine, Departments of Pediatrics, Obstetrics-Gynecology, Physiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262 TENSSON, RALL GIACOMO B., SUSAN . LENA MAR- Placental transfer as a function of uterine Mood . Am. J. Physiol. 242 (Heart Circ. Physiol. 11): H429-H436, 1982.-The effect of variations of uterine (F) on placental transfer was examined in six chronic sheep preparations by measuring the placental clearances of ethanol (C,) antipyrine (CA) at different levels of F. Norepinephrine infusion, hemorrhage, occlusion of the terminal aorta were used to reduce F below normal. The reduction of F had no appreciable effect on umbilical (f). In each ewe, CE significantly correlated with F. The CE vs. F relationship at constant f was curvilinear with convexity toward the clearance axis. Regression analysis showed that the equation l/& = l/.911 F + P/.831 f could account for most of the CE variance (4 = 0.97). Implicit in this relation is the concept that, given a certain level of placental perfusion, an F/ f ratio = 1 is optimal for the exchange of highly diffusible inert molecules between mother fetus [CE/(F + f) was maximum different
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Mar 1, 1982
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