1284 1286 1286 1286 1289 1290 1290 1291 1294 1298 1298 1298 1299 1302 1303 1304 1306 1306 1307 1310 I311 1312 1312 1312 1314 1316 1316 1317 1319 1322 1323 .... I. INTRODUCTION The detection growth factor (NGF) was the unexpected consequence experiments designed by Bueker (48) to evaluate the concept 0031-9333/80/000000-00$01.25 Copyright 0 1980 the American Physiological Society October PHYSIOLOGY GROWTH FACTOR that the volume peripheral tissues determines the degree development the innervating spinal motor and sensory systems (76, 115, 116). Indeed the transplantation mouse sarcoma tissue into the body wall young chick embryos did elicit a marked increase in the size the sensory ganglia supplying the area the tumor transplants (48). However, a more thorough inspection embryos bearing transplants mouse sarcomas 37 and 180 revealed that the effect was not confined to sensory ganglia and in fact involved the sympathetic ganglia even more so (185). It was Levi-Montalcini and Hamburger (185) who realized that not only ganglia adjacent to the tumor, but also those remote from it, were affected. They suggested that the sarcoma tissue released a diffusible factor into the circulation that was reponsible for the observed effects. Their hypothesis was substantiated by the
Physiological Reviews – The American Physiological Society
Published: Oct 1, 1980
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