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Physiological factors affecting O2 transport by hemoglobin in an in vitro capillary system

METHODS A complete description of the capillary flow system and the microspectrootometer was presented the precedg paper (4). The capillary is described mathematically as a cylder of radius R,. For homogeneous hemoglob solutions, axial convection, radial diffusion, and chemical reaction with the capillary are described L,, “y VZ w21 dz - Do 2’ a”[021 z+R’dR m21 dR + k[HbOz] (1a ) d[Hb02]’ dR - k’[O,][Hb] V’ ----- d[Hb02 dz d2[Hb02] + 1 dR2 R + k’[02][Hb] - k[Hb02] THE PRECEDG PAPER, an artificial Capillary System was described and tested for applicability studyg mass processes (4). th is work, the apparatus was used to assessexperi .mentally the effects of various ysiological parameters on the efficiency of O2 . A rigorous mathematical model was developed for analyzg quantitatively the mass properties of concentrated hemoglob solutions flowg through a small capillary embedded a slab of silicone rubber that was -170 pm thick. The capillary size was -27 pm diameter, which is analogous to that of small arterio les muscle tissue and the larger microvessels found mammalian livers. An examation of this system provides estimates of the effects of external O2tension, flow 0161-7567/87 $1.50 where Vz is the axial fluid velocity; R http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

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