4YSIOLOGY Vol. 45, No. 4, April I 98 I. Prted U.S.A. ROBERT RAMON F. MILLER, F. THOMAS E. FRUMKES, MALCOLM SLAUGHTER, AND Departments of Ophthalmology, Physiology, and Biophysics, Washgton University School of Medice, St. Louis, Missouri 631 IO; and Department of Psychology, Queens College, Flushg, New York I1 367 SUMMARY AND CONCLUSIONS 1. tracellular recordgs from identified and unidentified neurons of the mudpuppy were mataed a perfused -eyecup preparation. Putative transmitters y-amobutyric acid (BA) and glyce and the antagonists , bicuculle, and strychne were added to the bathg medium while monitorg put resistance, membrane potential, and lightevoked response properties of l neurons. 2. BA and glyce concentrations up to 10 mM did not effect photoreceptors; strychne, bicuculle, and did not fluence photoreceptor wave form. 3. Horizontal cells were depolarized if the BA and glyce concentration exceeded 2 mM; this effect was either absent or required a much larger dose if synaptic transmission was elimated with cobalt. Depolarizg bipolars were more BA than glyce sensitive while hyperpolarizg bipolars were comparatively more glyce sensitive. Depolarizg bipolars were enhanced by BA antagonists; hyperpolarizg bipolars were enhanced by strychne. These observations raise the possibility that bipolar cells are tonically affected by dark
Journal of Neurophysiology – The American Physiological Society
Published: Apr 1, 1981
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