Physiological and pharmacological basis of GABA and glycine action on neurons of mudpuppy retina. I. Receptors, horizontal cells, bipolars, and G-cells

Physiological and pharmacological basis of GABA and glycine action on neurons of mudpuppy retina.... 4YSIOLOGY Vol. 45, No. 4, April I 98 I. Prted U.S.A. ROBERT RAMON F. MILLER, F. THOMAS E. FRUMKES, MALCOLM SLAUGHTER, AND Departments of Ophthalmology, Physiology, and Biophysics, Washgton University School of Medice, St. Louis, Missouri 631 IO; and Department of Psychology, Queens College, Flushg, New York I1 367 SUMMARY AND CONCLUSIONS 1. tracellular recordgs from identified and unidentified neurons of the mudpuppy were mataed a perfused -eyecup preparation. Putative transmitters y-amobutyric acid (BA) and glyce and the antagonists , bicuculle, and strychne were added to the bathg medium while monitorg put resistance, membrane potential, and lightevoked response properties of l neurons. 2. BA and glyce concentrations up to 10 mM did not effect photoreceptors; strychne, bicuculle, and did not fluence photoreceptor wave form. 3. Horizontal cells were depolarized if the BA and glyce concentration exceeded 2 mM; this effect was either absent or required a much larger dose if synaptic transmission was elimated with cobalt. Depolarizg bipolars were more BA than glyce sensitive while hyperpolarizg bipolars were comparatively more glyce sensitive. Depolarizg bipolars were enhanced by BA antagonists; hyperpolarizg bipolars were enhanced by strychne. These observations raise the possibility that bipolar cells are tonically affected by dark http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

Physiological and pharmacological basis of GABA and glycine action on neurons of mudpuppy retina. I. Receptors, horizontal cells, bipolars, and G-cells

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Publisher
The American Physiological Society
Copyright
Copyright © 1981 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
Publisher site
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Abstract

4YSIOLOGY Vol. 45, No. 4, April I 98 I. Prted U.S.A. ROBERT RAMON F. MILLER, F. THOMAS E. FRUMKES, MALCOLM SLAUGHTER, AND Departments of Ophthalmology, Physiology, and Biophysics, Washgton University School of Medice, St. Louis, Missouri 631 IO; and Department of Psychology, Queens College, Flushg, New York I1 367 SUMMARY AND CONCLUSIONS 1. tracellular recordgs from identified and unidentified neurons of the mudpuppy were mataed a perfused -eyecup preparation. Putative transmitters y-amobutyric acid (BA) and glyce and the antagonists , bicuculle, and strychne were added to the bathg medium while monitorg put resistance, membrane potential, and lightevoked response properties of l neurons. 2. BA and glyce concentrations up to 10 mM did not effect photoreceptors; strychne, bicuculle, and did not fluence photoreceptor wave form. 3. Horizontal cells were depolarized if the BA and glyce concentration exceeded 2 mM; this effect was either absent or required a much larger dose if synaptic transmission was elimated with cobalt. Depolarizg bipolars were more BA than glyce sensitive while hyperpolarizg bipolars were comparatively more glyce sensitive. Depolarizg bipolars were enhanced by BA antagonists; hyperpolarizg bipolars were enhanced by strychne. These observations raise the possibility that bipolar cells are tonically affected by dark

Journal

Journal of NeurophysiologyThe American Physiological Society

Published: Apr 1, 1981

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