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MATERIALS AND METHODS ADIPOSE TISSUE (BAT) has been recognized as the most important site of nonshivering thermogenesis. It has been generally accepted that thermogenesis in BAT occurs not only in response to cold (9) but also in response to eating (22) and that this does not occur in some genetically obese animals (32). BAT is a rich source of type 2 iodothyronine 5â-deiodinase. The 3,5,3â-triiodothyronine (T3) produced from thyroxine (T4) by this enzyme is required for optimal synthesis of the BAT mitochondrial uncoupling (4) in response to cold stress. This enzyme also provides T, to the plasma pool of the cold-stressed rat (6, 26). In vivo, BAT type 2 iodothyronine 5â-deiodinase is activated by the sympathetic nervous system, an effect that is mediated by the ol-adrenergic receptor (27). al-Adrenergic stimulation has also been demonstrated in isolated (20) To elucidate the regulation of type 2 iodothyronine 5âdeiodinase, we explored the al-adrenergic pathway in these cells. Previous studies of Fain (7) showed that incubation of with al-agonists caused an increase in the incorporation of 32P into phosphatidylinositol. It is known that through the breakdown of phosphatidylinositol4,5-bisphosphate the two generated products, inositol trisphosphate and 1,2-diacylglycerol, can respectively mobilize intracellular calcium (3)
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Mar 1, 1988
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