Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Persistent detrusor overactivity in rats after relief of partial urethral obstruction

Persistent detrusor overactivity in rats after relief of partial urethral obstruction Abstract Detrusor overactivity (DO) persists after prostatectomy in 20% to 25% of patients with benign disease. Assuming that nonvoiding contractions (NVCs) can be used as a surrogate for DO in humans, the rat model of obstruction/deobstruction may allow us to study the pathophysiology of persistent DO after deobstruction. We investigated bladder function, with a special focus on NVCs, in rats by use of a new, modified method of obstruction and deobstruction and compared these results with those obtained by use of the conventional method. Seventy female Sprague-Dawley rats underwent 1 ) sham operation ( n = 10), 2 ) obstruction by a modified method (Modif-Obs; n = 12), 3 ) obstruction/deobstruction by the conventional method (Conv-Obs/Deobs; n = 13), or 4 ) obstruction/deobstruction by the modified method (Modif-Obs/Deobs; n = 35). The Modif-Obs/Deobs animals were divided into subgroups with (DO+) and without (DO−) NVCs. Two weeks after partial urethral obstruction, the animals were deobstructed, and 1 wk later cystometry was performed with recording of intravesical and intra-abdominal pressures. NVCs were shown in all groups: Modif-Obs (80%), Conv-Obs/Deobs (100%), and Modif-Obs/Deobs (40%). In the Modif-Obs/Deobs group, bladder weight and the muscle-to-collagen ratio were higher in DO+ than in DO− rats. The Modif-Obs/Deobs group showed no mortality compared with 25% mortality in the Conv-Obs/Deobs group. The modified method may be more adequate for studying persistent DO after deobstruction, because it resulted in pressure/volume- and DO-related parameters similar to those found in the clinical situation. The persistence of DO after deobstruction may partly be due to irreversible changes in the bladder caused during the period of obstruction. urinary bladder cystometry Copyright © 2011 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print July 2011 , doi: 10.​1152/​ajpregu.​00046.​2011 AJP - Regu Physiol October 2011 vol. 301 no. 4 R896-R904 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: ajpregu.00046.2011v1 301/4/R896 most recent Classifications Innovative Methodology Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Jin, L. Articles by Lee, T. PubMed PubMed citation Articles by Jin, L. Articles by Lee, T. Related Content Load related web page information Current Issue October 2011, 301 (4) Alert me to new issues of AJP - Regu Physiol About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2011 the American Physiological Society Print ISSN: 0363-6119 Online ISSN: 1522-1490 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview(); http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Persistent detrusor overactivity in rats after relief of partial urethral obstruction

Download PDF
10 pages

Loading next page...
 
/lp/the-american-physiological-society/persistent-detrusor-overactivity-in-rats-after-relief-of-partial-JhyjWlEMpp

References (42)

Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
DOI
10.1152/ajpregu.00046.2011
pmid
21795634
Publisher site
See Article on Publisher Site

Abstract

Abstract Detrusor overactivity (DO) persists after prostatectomy in 20% to 25% of patients with benign disease. Assuming that nonvoiding contractions (NVCs) can be used as a surrogate for DO in humans, the rat model of obstruction/deobstruction may allow us to study the pathophysiology of persistent DO after deobstruction. We investigated bladder function, with a special focus on NVCs, in rats by use of a new, modified method of obstruction and deobstruction and compared these results with those obtained by use of the conventional method. Seventy female Sprague-Dawley rats underwent 1 ) sham operation ( n = 10), 2 ) obstruction by a modified method (Modif-Obs; n = 12), 3 ) obstruction/deobstruction by the conventional method (Conv-Obs/Deobs; n = 13), or 4 ) obstruction/deobstruction by the modified method (Modif-Obs/Deobs; n = 35). The Modif-Obs/Deobs animals were divided into subgroups with (DO+) and without (DO−) NVCs. Two weeks after partial urethral obstruction, the animals were deobstructed, and 1 wk later cystometry was performed with recording of intravesical and intra-abdominal pressures. NVCs were shown in all groups: Modif-Obs (80%), Conv-Obs/Deobs (100%), and Modif-Obs/Deobs (40%). In the Modif-Obs/Deobs group, bladder weight and the muscle-to-collagen ratio were higher in DO+ than in DO− rats. The Modif-Obs/Deobs group showed no mortality compared with 25% mortality in the Conv-Obs/Deobs group. The modified method may be more adequate for studying persistent DO after deobstruction, because it resulted in pressure/volume- and DO-related parameters similar to those found in the clinical situation. The persistence of DO after deobstruction may partly be due to irreversible changes in the bladder caused during the period of obstruction. urinary bladder cystometry Copyright © 2011 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print July 2011 , doi: 10.​1152/​ajpregu.​00046.​2011 AJP - Regu Physiol October 2011 vol. 301 no. 4 R896-R904 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: ajpregu.00046.2011v1 301/4/R896 most recent Classifications Innovative Methodology Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Jin, L. Articles by Lee, T. PubMed PubMed citation Articles by Jin, L. Articles by Lee, T. Related Content Load related web page information Current Issue October 2011, 301 (4) Alert me to new issues of AJP - Regu Physiol About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2011 the American Physiological Society Print ISSN: 0363-6119 Online ISSN: 1522-1490 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();

Journal

AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society

Published: Oct 1, 2011

There are no references for this article.