tractile dysfunction (2, 7, 10). Indeed, the radical scavengers, superoxide dismutase plus catalase, have been shown in this laboratory to significantly improve postischemic function reduce reperfusion-induced ventricular fibrillation in acutely rat hearts (20). It is well known that hearts have an increased susceptibility to reperfusion-induced contractile failure. However, it is not known whether this increased risk is related to an impairment in vascular function. O purpose of the present study was to investigate endothelium-dependent relaxation with the use of isolated thoracic aorta obtaid from chronic rats. The rat model was chosen specifically to study the effects of diabetes on vascular function independent of the complications of atherosclerosis. Atherosclerosis per se has been shown to impair endothelium-dependent relaxation in rabbit aorta (10); however, it is well known that the rat is resistant to the development of atherosclerosis. The second purpose of this study was to determi whether oxygen-derived radicals showed any specificity for impairing endothelium-dependent vs. endothelium-independent relaxation in isolated vessels from chronic rats. METHODS DEVELOPMENT OF ATHEROSCLEROTIC DISEASE is o complication of chronic diabetes mellitus. Atherosclerosis produces histological evidence of endothelial alterations as well as changes in vascular function in patients in experimental animals (3,17,22). While much attention
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Oct 1, 1988
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