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Osmotic control of vasopressin with chronically altered volume states in anephric dogs

Osmotic control of vasopressin with chronically altered volume states in anephric dogs J. AND A. W. COWLEY, JR. and Division of Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226; Nephrology, University of Mississippi Medical Center, Jackson, Mississippi 39216 E.W., JR.,M. M. J.AND A.W. CQWLEY, JR. Osmotic of vasopressin with chronically altered volume states in anephric dbgs. Am. J. Physiol. 247 (Endocrinol. Metab. 10): E355-E361, 1984.--Continuous peritoneal dialysis has been used to maintain anephric dogs at chronically sustained low, normal, and high volume states in order to study the long-term interaction of volume and osmotic stimuli in the of plasma vasopressin (PA&. Bilaterally nephrectomized dogs were maintained for I-3 mo with normal plasma sodium and potassium levels and blood urea nitrogen of 70.1 -+ 10.8 mg/dl. During the first month, the dogs were dialysized to each of the three volume states. After each volume state had been maintained for 7 days, an osmotic forcing with intravenous distilled Hz0 and hypertonic NaCl was performed in the conscious state to quantitate the relationship between plasma osmolality (Poem) and P AyP- During the osmotic forcings left atria1 pressure () averaged -2.4 -+- 0.5, 2,6 & 0.8, and 11.9 -t 1.1 cmH&; mean arterial pressure averaged 113 t 11, 125 k 10, and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Osmotic control of vasopressin with chronically altered volume states in anephric dogs

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Publisher
The American Physiological Society
Copyright
Copyright © 1984 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
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Abstract

J. AND A. W. COWLEY, JR. and Division of Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226; Nephrology, University of Mississippi Medical Center, Jackson, Mississippi 39216 E.W., JR.,M. M. J.AND A.W. CQWLEY, JR. Osmotic of vasopressin with chronically altered volume states in anephric dbgs. Am. J. Physiol. 247 (Endocrinol. Metab. 10): E355-E361, 1984.--Continuous peritoneal dialysis has been used to maintain anephric dogs at chronically sustained low, normal, and high volume states in order to study the long-term interaction of volume and osmotic stimuli in the of plasma vasopressin (PA&. Bilaterally nephrectomized dogs were maintained for I-3 mo with normal plasma sodium and potassium levels and blood urea nitrogen of 70.1 -+ 10.8 mg/dl. During the first month, the dogs were dialysized to each of the three volume states. After each volume state had been maintained for 7 days, an osmotic forcing with intravenous distilled Hz0 and hypertonic NaCl was performed in the conscious state to quantitate the relationship between plasma osmolality (Poem) and P AyP- During the osmotic forcings left atria1 pressure () averaged -2.4 -+- 0.5, 2,6 & 0.8, and 11.9 -t 1.1 cmH&; mean arterial pressure averaged 113 t 11, 125 k 10, and

Journal

AJP - Endocrinology and Metabolism – The American Physiological Society

Published: Sep 1, 1984

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