Opioids contribute to hypoxia-induced pial artery dilation through activation of ATP-sensitive K+ channels

Opioids contribute to hypoxia-induced pial artery dilation through activation of ATP-sensitive K+... pial artery K+ channels of Pennsylvania V. SHANKAR W. M. ARMSTEAD Departments of Anesthesia Pharmacology, The University Hospital of Philadelphia, Philadelphia, Pennsvlvania 19104 the Children’s Shankar, V., W. M. Armstead. contribute to hypoxia-induced pial artery through activation of ATP-sensitive K+ channels. Am. J. Physiol. 269 (Heart Circ. PhysioZ. 38): H997-H1002, 1995.-It has been previously observed that hypoxia increases cerebrospinal fluid (CSF) methionine enkephalin leucine enkephalin levels, these contribute to hypoxia-induced pial artery vaso. The present study was designed to investigate whether the activation of ATP-sensitive K+ channels (KA& mediates the contribution of to the hypoxia-induced pial artery . The closed-cranial window technique was used to measure pial diameter in newborn pigs. Glibenclamide (10s6 M), a KATP inhibitor, attenuated the resulting from moderate severe hypoxia [23 t 1 33 * 2% vs. 7 2 1 18 t 2%, respectively, for moderate severe hypoxia (arterial PO, = 35 25 mmHg, respectively) in the absence vs. presence of glibenclamide]. In addition, glibenclamide attenuated the produced by methionine enkephalin (loss 10m6 M) (13 t 1 vs. 4 * 2% 21 2 2 vs. 7 t 3%, respectively, for methionine enkephalin in the absence presence of glibenclamide). Leucine enkephalin-induced was similarly attenuated by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Opioids contribute to hypoxia-induced pial artery dilation through activation of ATP-sensitive K+ channels

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Publisher
The American Physiological Society
Copyright
Copyright © 1995 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
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Abstract

pial artery K+ channels of Pennsylvania V. SHANKAR W. M. ARMSTEAD Departments of Anesthesia Pharmacology, The University Hospital of Philadelphia, Philadelphia, Pennsvlvania 19104 the Children’s Shankar, V., W. M. Armstead. contribute to hypoxia-induced pial artery through activation of ATP-sensitive K+ channels. Am. J. Physiol. 269 (Heart Circ. PhysioZ. 38): H997-H1002, 1995.-It has been previously observed that hypoxia increases cerebrospinal fluid (CSF) methionine enkephalin leucine enkephalin levels, these contribute to hypoxia-induced pial artery vaso. The present study was designed to investigate whether the activation of ATP-sensitive K+ channels (KA& mediates the contribution of to the hypoxia-induced pial artery . The closed-cranial window technique was used to measure pial diameter in newborn pigs. Glibenclamide (10s6 M), a KATP inhibitor, attenuated the resulting from moderate severe hypoxia [23 t 1 33 * 2% vs. 7 2 1 18 t 2%, respectively, for moderate severe hypoxia (arterial PO, = 35 25 mmHg, respectively) in the absence vs. presence of glibenclamide]. In addition, glibenclamide attenuated the produced by methionine enkephalin (loss 10m6 M) (13 t 1 vs. 4 * 2% 21 2 2 vs. 7 t 3%, respectively, for methionine enkephalin in the absence presence of glibenclamide). Leucine enkephalin-induced was similarly attenuated by

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Sep 1, 1995

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