S. ZWASS, MARIE LAU, DENNIS M. FISHER University California, San Francisco, California 94143-0648 affected by maturational changes the blood-bra barrier. To expla possible differences the maturational response to morphe , we vestigated their effects on ventilation. The examation pharmacoketics, , equilibration between plasma opioid concentrations effect permitted us to determe the etiology maturational changes the ventilatory effects these opioids. Our results suggest a new explanation for sensitivity the neonate to morphe. METHODS Bragg, Paul, Maurice S. Zwass, Marie Lau, Dennis M. Fisher. Opioid neonatal dogs: differences between morphe . J. AppZ. PhysioZ. 79(5): 1X9- 1524,1995. -Clical experience laboratory studies suggest that are more sensitive than adults to the ventilatory depressant effects morphe. Similar sensitivity has been cited, but not demonstrated, for . To exame this issue, we determed ventilatory morphe 28 dogs aged 2-35 days. Durg isohypercapnia, morphe or was fused to depress mute ventilation by >50% arterial plasma opioid concentrations were measured. For each drug, an effect compartment pharmacodynamic model was fit to the values for mute ventilation to determe the steadystate opioid plasma concentration depressg ventilation by 50% (C& the rate constant for equilibration between plasma concentration effect (k,,). For morphe, there was a marked age-related
Journal of Applied Physiology – The American Physiological Society
Published: Nov 1, 1995
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