Opioid growth factor modulates corneal epithelial outgrowth in tissue culture

Opioid growth factor modulates corneal epithelial outgrowth in tissue culture contributes to maintaining the optical clarity of the cornea provides a major protective barrier for the underlying cornea (8). The complete reepithelialization of the cornea after trauma or surgery is essential for the restitution of normal visual function (11). Thus knowledge about the maintenance repair of the cornea1 is extremely important. The role of growth factors in maintaining normal structure function of the cornea, in the healing of the cornea1 , has emerged in the past few years (17, 20). A number of growth factors /or receptors have been identified in cornea1 their gene expression detected (6, 7,10,15-17, 20, 2%25), but understing about their role in biology in health diseaseremains incomplete. Endogenous receptors were originally thought to be related to neural modulation (l), but it is now clear that opioid peptides act as growth regulators in many normal malignant tissues (28, 30). An opioid growth factor (OGF), the pentapeptide [Met5]enkephalin, has been identified in both eukaryotes prokaryotes as a potent inhibitor of cell replication THE R942 0363-6119/95 $3.00 Copyright o 1995 (28-30, 33). I n vertebrates, OGF is also thought to be important in cellular maturation survival (13, 30). OGF has been documented to be produced in an http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Opioid growth factor modulates corneal epithelial outgrowth in tissue culture

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Publisher
The American Physiological Society
Copyright
Copyright © 1995 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
See Article on Publisher Site

Abstract

contributes to maintaining the optical clarity of the cornea provides a major protective barrier for the underlying cornea (8). The complete reepithelialization of the cornea after trauma or surgery is essential for the restitution of normal visual function (11). Thus knowledge about the maintenance repair of the cornea1 is extremely important. The role of growth factors in maintaining normal structure function of the cornea, in the healing of the cornea1 , has emerged in the past few years (17, 20). A number of growth factors /or receptors have been identified in cornea1 their gene expression detected (6, 7,10,15-17, 20, 2%25), but understing about their role in biology in health diseaseremains incomplete. Endogenous receptors were originally thought to be related to neural modulation (l), but it is now clear that opioid peptides act as growth regulators in many normal malignant tissues (28, 30). An opioid growth factor (OGF), the pentapeptide [Met5]enkephalin, has been identified in both eukaryotes prokaryotes as a potent inhibitor of cell replication THE R942 0363-6119/95 $3.00 Copyright o 1995 (28-30, 33). I n vertebrates, OGF is also thought to be important in cellular maturation survival (13, 30). OGF has been documented to be produced in an

Journal

AJP - Regulatory, Integrative and Comparative PhysiologyThe American Physiological Society

Published: Apr 1, 1995

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