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developments for glucose . Am. J. Physiol. 252 (Endocrinol. Metab): E679-E689,1987.-The model proposed by Steele (Ann. NY Acad. Sci. 82: 420-430, 1959) to compute rates of appearance and disappearance in non-steady state is subjected to theoretical analysis. It is shown that this model introduces an error with two components, one dependent on the volume of the compartment, the other related to the complex configuration of the system. The errors depend on the time course of specific activity, change differently with time, and may take the opposite sign but they do not, in general, cancel each other. Corollaries of this analysis are the following: there is no single pool-fraction value satisfactory under all situations; keeping tracer specific activity as constant as possible during the experiment minimizes both errors; and non-steadystate analysis demands proper modeling of the system. Tracer experiments were carried out in five normal volunteers. Plasma [ 3-3H]glucsse concentration was first brought to equilibrium by means of a primed constant 2-h infusion, and then the steady state was perturbed by a 2-h euglycemic insulin (1 mU 0 mine1 kg-â) clamp, realizing a transition between a basal and a euglycemic hyperinsulinemic steady state. These data were analyzed with Steeleâs
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: May 1, 1987
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