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Cohen, Gordon A., Adrian J. Hobbs, Richard M. Fitch, Michael J. Zinner, Gautam Chaudhuri, and Louis J. Ignarro. Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed . Am. J. Physiol. 271 (Heart Circ. Physiol. 40): Hl33H139, 1996.-The objective of this study was to determine whether nitric oxide (NO) could function as a modulator of endothelium-dependent vasodilation . To this end, the influence of exogenous NO on vasodilator responses in the rabbit hindquarters vascular bed was determined. Previous in vitro studies have demonstrated that NO inhibits both neuronal NO synthase from rat cerebellum as well as NO synthase derived from bovine aortic endothelial cells. The present study was conducted in the rabbit hindquarters vascular bed under conditions of constant blood flow so that changes in pressure directly reflected changes in vascular resistance. Under these conditions, the NO donor agent S-nitroso-N-acetylpenicillamine (SNAP) reversibly attenuated responses to the endotheliumdependent vasodilators, acetylcholine and bradykinin. In contrast, SNAP did not influence the endothelium-independent vasodilator response to SNAP itself or to &bromoguanosine 3â,5â-cyclic monophosphate. These observations indicate clearly that NO interferes with endothelium-dependent vasodilator action and support the view that endogenous NO may actually play a physiological role in regulating vascular
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Jul 1, 1996
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