JEFFREY M. GIDDAY Y-UN ZHU Departments of Neurology Neurological Surgery, Ophthalmology Biology Physiology, Washington University School of Medicine, Gidday, Jeffrey M., Yun Zhu. does not mediate auto of in newborn pig. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H1065-H1072, 1995.-Isoflurane-anesthetized newborn pigs were used to test the hypothesis that mediates autoregulatory dilations of arterioles. Fundus images were monitored by videomicroscopy at x 310, stimulus-induced changes in arteriolar diameter were measured by on-line image analysis. Dilatative responses to systemic hypoxia (arterial O2 tension 20-30 mmHg), hypotension (mean arterial pressure 40 mmHg), or hypercapnia (arterial COZ tension 70-85 mmHg) were assessed after intravitreal microsuffusion of the synthase inhibitor NG-monomethyl-Larginine (L-NMMA) over the observed arterioles. Twenty-five nanomoles L-NMMA constricted arterioles by 24 2 2% (P < 0.01; n = 17 pigs); a significant constriction (14 * 2%) was still observed 80 min after drug administration (n = 5). Complete synthase inhibition at this dose was indicated by the findings that co-administration of 2.5 pmol L-arginine reversed this constriction within 17 ? 2 min (n = 3), that L-NMMA, but not D-NMMA, completely inhibited the 20 * 3% (P < 0.01) arteriolar dilation induced by intravitreal acetylchowas line (7.5 nmol; n
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Sep 1, 1995
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