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Nitric oxide and pregnancy

Sladek, Stephen M., Ronald R. Magness, Kirk I? Conrad. Nitric oxide pregnancy. Am. J. PhysioZ. 272 (Regzdatory Integrative Comp. PhysioZ. 41): R441-R463,1997.-This review will consider whether nitric oxide (NO) contributes to maternal systemic vasodilation during pregnancy, regulates uterine fetoplacental blood flow, is involved in uterine quiescence prior to parturition. Also, whether a deficiency of NO contributes to the hypertensive disorder of pregnancy, preeclampsia, will be considered. The biosynthesis of NO increases in gravid rats sheep, but the status in normal human pregnancy preeclampsia is controversial. NO contributes to maternal systemic vasodilation reduced vascular reactivity during normal pregnancy; however, the relative contribution of NO is variable depending on the animal , vascular bed, vessel size. Impaired relaxation responses to acetylcholine, but not bradykinin or NO donors, are observed in small arteries from women with preeclampsia, suggesting a receptor or signal transduction defect, although NO may play little, if any, role here. Uterine arteries have increased endothelial nitric oxide synthase (NOS) activity, protein expression, guanosine 3’,5’-cyclic monophosphate production during pregnancy; however, whether these mediate uterine vasodilation during pregnancy remains to be established. NOS is expressed in the human placental syncytiotrophoblast in the fetoplacental umbilical vascular endothelium where basal production of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

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