Morris, Sidney M., Jr. and Timothy R. Billiar. New insights into the regulation of inducible nitric oxide synthesis. Am. J. PhysioZ. 266 (EndocrinoZ. Metab. 29): E829-E839, 1994.-Recent studies have identified the induction of nitric oxide (NO) synthesis in many cell types as part of the host response to sepsis and inflammation. Induced NO can have a variety of effects which may be detrimental or beneficial during sepsis or inflammation, depending on amount, duration, and anatomic site of synthesis. As arginine is the only physiological nitrogen donor for NO synthesis, metabolism of this amino acid may play an important role in regulation of NO synthesis during sepsis. This will discuss the roles NO plays in sepsis and the potential impact of arginine metabolism on NO synthesis. inducible nitric oxide synthase; arginine; sepsis; inflammation OXIDE (NO), an atmospheric gas and one of the toxic components of air pollution, is now known to be enzymatically synthesized in a tightly regulated manner in a number of tissues and cell types. The smallest product of mammalian cells, this simple short-lived molecule mediates functions as diverse as cell-cell signaling and immune-mediated cytotoxicity. Thus regulation of the timing and amount of NO produced, as well
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Jun 1, 1994
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