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Neural Representations of Complex Temporal Modulations in the Human Auditory Cortex

Neural Representations of Complex Temporal Modulations in the Human Auditory Cortex Abstract Natural sounds such as speech contain multiple levels and multiple types of temporal modulations. Because of nonlinearities of the auditory system, however, the neural response to multiple, simultaneous temporal modulations cannot be predicted from the neural responses to single modulations. Here we show the cortical neural representation of an auditory stimulus simultaneously frequency modulated (FM) at a high rate, f FM ≈ 40 Hz, and amplitude modulation (AM) at a slow rate, f AM <15 Hz. Magnetoencephalography recordings show fast FM and slow AM stimulus features evoke two separate but not independent auditory steady-state responses (aSSR) at f FM and f AM , respectively. The power, rather than phase locking, of the aSSR of both decreases with increasing stimulus f AM . The aSSR at f FM is itself simultaneously amplitude modulated and phase modulated with fundamental frequency f AM , showing that the slow stimulus AM is not only encoded in the neural response at f AM but also encoded in the instantaneous amplitude and phase of the neural response at f FM . Both the amplitude modulation and phase modulation of the aSSR at f FM are most salient for low stimulus f AM but remain observable at the highest tested f AM (13.8 Hz). The instantaneous amplitude of the aSSR at f FM is successfully predicted by a model containing temporal integration on two time scales, ∼25 and ∼200 ms, followed by a static compression nonlinearity. Copyright © 2009 the American Physiological Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

Neural Representations of Complex Temporal Modulations in the Human Auditory Cortex

Ding, Nai; Simon, Jonathan Z.
Journal of Neurophysiology , Volume 102 (5): 2731 – Nov 1, 2009
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Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
DOI
10.1152/jn.00523.2009
pmid
19692508
Publisher site
See Article on Publisher Site

Abstract

Abstract Natural sounds such as speech contain multiple levels and multiple types of temporal modulations. Because of nonlinearities of the auditory system, however, the neural response to multiple, simultaneous temporal modulations cannot be predicted from the neural responses to single modulations. Here we show the cortical neural representation of an auditory stimulus simultaneously frequency modulated (FM) at a high rate, f FM ≈ 40 Hz, and amplitude modulation (AM) at a slow rate, f AM <15 Hz. Magnetoencephalography recordings show fast FM and slow AM stimulus features evoke two separate but not independent auditory steady-state responses (aSSR) at f FM and f AM , respectively. The power, rather than phase locking, of the aSSR of both decreases with increasing stimulus f AM . The aSSR at f FM is itself simultaneously amplitude modulated and phase modulated with fundamental frequency f AM , showing that the slow stimulus AM is not only encoded in the neural response at f AM but also encoded in the instantaneous amplitude and phase of the neural response at f FM . Both the amplitude modulation and phase modulation of the aSSR at f FM are most salient for low stimulus f AM but remain observable at the highest tested f AM (13.8 Hz). The instantaneous amplitude of the aSSR at f FM is successfully predicted by a model containing temporal integration on two time scales, ∼25 and ∼200 ms, followed by a static compression nonlinearity. Copyright © 2009 the American Physiological Society

Journal

Journal of Neurophysiology – The American Physiological Society

Published: Nov 1, 2009

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