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Neural control of relaxation in cat airways smooth muscle

Neural control of relaxation in cat airways smooth muscle RALPH J., JOHNL. LOUIS . Neural control relaxation in smooth muscle. J. Respirat. Environ. Exercise Physiol. 57(5): Appl. Physiol.: 1536-1544, 1984.-Functional smooth muscle was examined in isolated segments trachea bronchi using electrical field stimulation (EFS) techniques. Field stimulation caused contraction in tissues at resting tone biphasic responses (contraction followed by relaxation) in tissues precontracted with 5-hydroxytryptamine (5-HT). Contractions were abolished by 10v6 M atropine. Inhibitory responses were dependent on voltage, duration, . At low voltages (110 V) pulse durations (10.3 ms), EFS induced relaxations were abolished by 3 x 10m6 M tetrodotoxin (TTX). Greater stimulus parameters elicited TTX-resistant relaxations, Pretreatment the tissues with 10m6 M propranolol 10m5 M guanethidine caused rightward shifts in relaxation -response curves. These findings indie that are innervated by excitatory cholinergic, inhibitory adrenergic, inhibitory nonadrenergic noncholinergic (NANC) nerves. Pretreatment the tissues with hexamethonium, cimetidine, indomethacin, or nordihydroguaiaretic acid did not affect NANC relaxation responses. It is concluded that NANC inhibitory responses in airway smooth muscle are mediated through intrinsic postganglionic nerve fibers occur independently histamine &-receptor activation without involvement cyclooxygenase or lipoxygenase products arachidonic acid metabolism. nonadrenergic gic inhibitory noncholinergic inhibitory ; ; electrical field stimulation adrener- tissues in the presence cholinergic adrenergic blocking http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Neural control of relaxation in cat airways smooth muscle

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Publisher
The American Physiological Society
Copyright
Copyright © 1984 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
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Abstract

RALPH J., JOHNL. LOUIS . Neural control relaxation in smooth muscle. J. Respirat. Environ. Exercise Physiol. 57(5): Appl. Physiol.: 1536-1544, 1984.-Functional smooth muscle was examined in isolated segments trachea bronchi using electrical field stimulation (EFS) techniques. Field stimulation caused contraction in tissues at resting tone biphasic responses (contraction followed by relaxation) in tissues precontracted with 5-hydroxytryptamine (5-HT). Contractions were abolished by 10v6 M atropine. Inhibitory responses were dependent on voltage, duration, . At low voltages (110 V) pulse durations (10.3 ms), EFS induced relaxations were abolished by 3 x 10m6 M tetrodotoxin (TTX). Greater stimulus parameters elicited TTX-resistant relaxations, Pretreatment the tissues with 10m6 M propranolol 10m5 M guanethidine caused rightward shifts in relaxation -response curves. These findings indie that are innervated by excitatory cholinergic, inhibitory adrenergic, inhibitory nonadrenergic noncholinergic (NANC) nerves. Pretreatment the tissues with hexamethonium, cimetidine, indomethacin, or nordihydroguaiaretic acid did not affect NANC relaxation responses. It is concluded that NANC inhibitory responses in airway smooth muscle are mediated through intrinsic postganglionic nerve fibers occur independently histamine &-receptor activation without involvement cyclooxygenase or lipoxygenase products arachidonic acid metabolism. nonadrenergic gic inhibitory noncholinergic inhibitory ; ; electrical field stimulation adrener- tissues in the presence cholinergic adrenergic blocking

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Nov 1, 1984

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