Cardiology, Department of Physiology, Wnipeg, Canada R3E 0 W3 . Myocardial Faculty of Medice, cation contents durg duction of calcium . Am. J. Physiol. 237(6): H713-H719, 1979 or Am. J. Physiol.: Heart Circ. Physiol. 6(6): H713-H719, 1979.-Myocardial cation contents were measured isolated rat hearts perfused under various conditions. Reperfusion of Ca2+-deprived hearts produced marked creases myocardial Ca2+ Naâ decreases Mg+ K+ contents. These changes were dependent on the Ca2+ concentration duration of perfusion durg the periods of Ca2+ deprivation reperfusio The loss of Ca2â Kâ contents normally seen after Ca2+-free exposure as well as the reperfusion-duced changes were prevented if the Ca2%ee medium contaed low (35 mM) Na+ or was cooled to 21Â°C. Reperfusion with normal Ca2â, low Na+ medium augmented the crease myocardial Ca2+ content, while reducg Kâ or Mg2+ or creasg M&â the reperfusion medium had no effect. Addition of verapam.& Dm, or propranolol to the reperfusion solution did not alter the reperfusion-duced cation changes observed usg medium; These data suggest that durg Ca2â depletion, the mechanisms responsible for regulatg calcium flux are either lost or activated, so that reperfusion-duced changes are governed solely by the drivg force favorg calcium flux. The occurrence of Ca2â overload
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Dec 1, 1979
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