Myocardial cation contents during induction of calcium paradox

Myocardial cation contents during induction of calcium paradox Cardiology, Department of Physiology, Wnipeg, Canada R3E 0 W3 . Myocardial Faculty of Medice, cation contents durg duction of calcium . Am. J. Physiol. 237(6): H713-H719, 1979 or Am. J. Physiol.: Heart Circ. Physiol. 6(6): H713-H719, 1979.-Myocardial cation contents were measured isolated rat hearts perfused under various conditions. Reperfusion of Ca2+-deprived hearts produced marked creases myocardial Ca2+ Na’ decreases Mg+ K+ contents. These changes were dependent on the Ca2+ concentration duration of perfusion durg the periods of Ca2+ deprivation reperfusio The loss of Ca2’ K’ contents normally seen after Ca2+-free exposure as well as the reperfusion-duced changes were prevented if the Ca2%ee medium contaed low (35 mM) Na+ or was cooled to 21°C. Reperfusion with normal Ca2’, low Na+ medium augmented the crease myocardial Ca2+ content, while reducg K’ or Mg2+ or creasg M&’ the reperfusion medium had no effect. Addition of verapam.& Dm, or propranolol to the reperfusion solution did not alter the reperfusion-duced cation changes observed usg medium; These data suggest that durg Ca2’ depletion, the mechanisms responsible for regulatg calcium flux are either lost or activated, so that reperfusion-duced changes are governed solely by the drivg force favorg calcium flux. The occurrence of Ca2’ overload http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Myocardial cation contents during induction of calcium paradox

Loading next page...
 
/lp/the-american-physiological-society/myocardial-cation-contents-during-induction-of-calcium-paradox-PsVX7Qz9l8
Publisher
The American Physiological Society
Copyright
Copyright © 1979 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

Cardiology, Department of Physiology, Wnipeg, Canada R3E 0 W3 . Myocardial Faculty of Medice, cation contents durg duction of calcium . Am. J. Physiol. 237(6): H713-H719, 1979 or Am. J. Physiol.: Heart Circ. Physiol. 6(6): H713-H719, 1979.-Myocardial cation contents were measured isolated rat hearts perfused under various conditions. Reperfusion of Ca2+-deprived hearts produced marked creases myocardial Ca2+ Na’ decreases Mg+ K+ contents. These changes were dependent on the Ca2+ concentration duration of perfusion durg the periods of Ca2+ deprivation reperfusio The loss of Ca2’ K’ contents normally seen after Ca2+-free exposure as well as the reperfusion-duced changes were prevented if the Ca2%ee medium contaed low (35 mM) Na+ or was cooled to 21°C. Reperfusion with normal Ca2’, low Na+ medium augmented the crease myocardial Ca2+ content, while reducg K’ or Mg2+ or creasg M&’ the reperfusion medium had no effect. Addition of verapam.& Dm, or propranolol to the reperfusion solution did not alter the reperfusion-duced cation changes observed usg medium; These data suggest that durg Ca2’ depletion, the mechanisms responsible for regulatg calcium flux are either lost or activated, so that reperfusion-duced changes are governed solely by the drivg force favorg calcium flux. The occurrence of Ca2’ overload

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Dec 1, 1979

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off