ysis during exercise: dual by epinephrine a contractions. Am. J. Physiol. 242 (Eocrinol. Mab. 5): E25-E32, 1982.-The interaction epinephrine a contractions on mabolism was studied in the isolated perfused rat hiquarter. Subtanic contractions (180/min) through 20 min elicited a increased phosphorylase a activity. In the soleus, a slow-twitch red , these effects were transient, but when epinephrine at a physiological concentration (2.4 x 10e8 M) was added to the perfusate, a phosphorylase activity were sustained throughout contractions. At this high frequency contractions, the effect epinephrine was much smaller in the fast-twitch red fibers a not significant in the fast-twitch white fibers the gastrocnemius . However, during less frequent contractions (30/ min) epinephrine increased a phosphorylase a activity in fast-twitch . The data suggest that epinephrine a contractions exert a dual during exercise: contractions principally stimulate early in exercise, a a direct effect epinephrine on is needed for continued . In addition, epinephrine increased oxygen consumption a glucose uptake in both resting a electrically stimulated hiquarters a, uer some coitions, it had a positive inotropic effect on contracting . catecholamines; perfused hiquarter; gen; mabolism; contraction; uptake; free fatty acids phosphorylase; fatigue; glycooxygen contractions accounts for the in (11,32). However,
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Jan 1, 1982
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