Molecular biology of voltage-dependent potassium channels

Molecular biology of voltage-dependent potassium channels in U.S.A. Zentrum fiir Molekulare Universit&t Hamburg, Neurobiologie, Institut fiir Neurale Signalverarbeitung, Hamburg, Federal Republic Germany I. Introduction .......................................................................................... II. Cloning Characterization Channel Superfamily ................................. A. Shaker ....................................................................... B. Shaker channel inactivation ...................................................................... C. Shaker channel gating ............................................................................ D. Shaker channel selectivity ........................................................................ E. channel gene family in DrosophiZa ................................................... F. channel families in vertebrates ....................................................... G. Novel properties vertebrate A-type ................................................. III. Pharmacology Cloned ....................................................... A. Tetraethylammonium ............................................................................. B. Charybdotoxin .................................................................................... C. Dendrotoxin ....................................................................................... IV. Structural Model Channel ............................................................. V. Identified Native .......................................... A. Shaker ....................................................................... B. in lymphocytes .............................................................. C. in pituitary .................................................................. D. Native in heart .............................................................. VI. Human Channel Genes ................................................................... VII. Concluding Remarks ................................................................................. INTRODUCTION S69 s70 s70 s70 s72 s74 s74 s75 s77 s77 S78 s79 S80 S81 S82 S82 S83 S83 S83 S84 S84 The idea that outward currents underlie the repolarization action potentials originates from the now classical electrophysiological studies Hodgkin Huxley (34). They proposed that depolarization a membrane leads to a delayed activation rectifying currents. The purpose these currents is to repolarize the membrane. Hence, the through which these repolarizing outward currents flow were termed delayed rectifier . These are selective for K ions which permeate the pore the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physiological Reviews The American Physiological Society

Molecular biology of voltage-dependent potassium channels

Physiological Reviews, Volume 72: S69 – Oct 1, 1992

Loading next page...
 
/lp/the-american-physiological-society/molecular-biology-of-voltage-dependent-potassium-channels-6YAOVBem9K
Publisher
The American Physiological Society
Copyright
Copyright © 1992 the American Physiological Society
ISSN
0031-9333
eISSN
1522-1210
Publisher site
See Article on Publisher Site

Abstract

in U.S.A. Zentrum fiir Molekulare Universit&t Hamburg, Neurobiologie, Institut fiir Neurale Signalverarbeitung, Hamburg, Federal Republic Germany I. Introduction .......................................................................................... II. Cloning Characterization Channel Superfamily ................................. A. Shaker ....................................................................... B. Shaker channel inactivation ...................................................................... C. Shaker channel gating ............................................................................ D. Shaker channel selectivity ........................................................................ E. channel gene family in DrosophiZa ................................................... F. channel families in vertebrates ....................................................... G. Novel properties vertebrate A-type ................................................. III. Pharmacology Cloned ....................................................... A. Tetraethylammonium ............................................................................. B. Charybdotoxin .................................................................................... C. Dendrotoxin ....................................................................................... IV. Structural Model Channel ............................................................. V. Identified Native .......................................... A. Shaker ....................................................................... B. in lymphocytes .............................................................. C. in pituitary .................................................................. D. Native in heart .............................................................. VI. Human Channel Genes ................................................................... VII. Concluding Remarks ................................................................................. INTRODUCTION S69 s70 s70 s70 s72 s74 s74 s75 s77 s77 S78 s79 S80 S81 S82 S82 S83 S83 S83 S84 S84 The idea that outward currents underlie the repolarization action potentials originates from the now classical electrophysiological studies Hodgkin Huxley (34). They proposed that depolarization a membrane leads to a delayed activation rectifying currents. The purpose these currents is to repolarize the membrane. Hence, the through which these repolarizing outward currents flow were termed delayed rectifier . These are selective for K ions which permeate the pore the

Journal

Physiological ReviewsThe American Physiological Society

Published: Oct 1, 1992

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off