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Aspects WRIGHT Biology AND SHIRO KANEGASAKI University School Medicine, and Microbiology, Boston, Massachusetts Tufts Cellular Structure Lipid Localization. ..................................................... ................................................................ :l and its linkage to R-core. ........................................ R-core. ............................................................... 0-polysaccharide. ...................................................... Physical properties. ..................................................... Lipopolysaccharide R-core synthesis 0-polysaccharide Biosynthesis. in cell-free synthesis ............................................ systems. ...................................... in cell-free systems. ............................. ................................. Synthesis. ........................ hlodification 0-polysaccharide structure Ligase reaction. ........................................................ Genetics and Control Lipopoiysaccharide R-core biosynthcsis--rfa genes. O-repeating sequence synthesis-rfb Polymerization 0-polysaccharide+c ........................................... genes. ................................. genes. ............................ ................... Phage control 0-polysaccharide synthesis-conversion. Control lipopolysaccharide synthesis. ..................................... Function. ............................................................... Interactions with host animal ............................................. Interactions Cellular Concluding with functions. Remarks. bacteriophages. ......................................... ..................................................... ........................................................ LIKE ALL OTHER CELLS, consist a cytoplasm bounded by a membrane. Immediately adjacent and external to this cytoplasmic membrane is the peptidoglycan or rigid layer that gives shape and mechanical strength to the cell. Grampositive organisms such as Staphylococci, Streptococci, and Bacilli are bounded by these two structures and in addition they also contain a unique macromolecular species called the teichoic acids. In Gram-negative organisms such as Escherichia coli and SaZmoneZla the rigid layer is surrounded by a complex envelope containing protein, phospholipid, and lipopolysaccharide. The latter component, which is specific to Gram-negative cells determines their 0-antigenic
Physiological Reviews – The American Physiological Society
Published: Oct 1, 1971
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